发明申请
US20140272998A1 DIAGNOSTIC MICRORNA PROFILING IN CUTANEOUS T-CELL LYMPHOMA (CTCL)
审中-公开
无菌T细胞淋巴瘤（CTCL）诊断微阵列
- 专利标题： DIAGNOSTIC MICRORNA PROFILING IN CUTANEOUS T-CELL LYMPHOMA (CTCL)
- 专利标题（中）： 无菌T细胞淋巴瘤（CTCL）诊断微阵列
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申请号： US14232806申请日： 2012-07-13
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公开(公告)号： US20140272998A1公开(公告)日： 2014-09-18
- 发明人: Ulrik Ralfkiaer , Peter Hagedorn , Charlotte Busch Ahler , Carsten Geisler , Anders Woetmann , Lone Skov , Niels Feentved Odum , Elisabeth Ralfkiaer
- 申请人： Ulrik Ralfkiaer , Peter Hagedorn , Charlotte Busch Ahler , Carsten Geisler , Anders Woetmann , Lone Skov , Niels Feentved Odum , Elisabeth Ralfkiaer
- 申请人地址： DK Ballerup DK Copenhagen K DK Copenhagen Ø DK Hellerup
- 专利权人： LEO PHARMA A/S,COPENHAGEN UNIVERSITY,RIGSHOSPITALET,GENTOFTE HOSPITAL
- 当前专利权人： LEO PHARMA A/S,COPENHAGEN UNIVERSITY,RIGSHOSPITALET,GENTOFTE HOSPITAL
- 当前专利权人地址： DK Ballerup DK Copenhagen K DK Copenhagen Ø DK Hellerup
- 国际申请： PCT/IB2012/001702 WO 20120713
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The present invention relates to the field of cancer-diagnostics. In particular the invention relates to a microRNA expression signature that allows discriminating skin samples of cutaneous T-cell lymphomas (CTCL) from non-malignant (inflammantory) skin samples by use of quantitative polymerase chain reaction performed on reverse transcribed miRNA. miR-155, miR-326, miR-663b, miR-203 and miR-205 are shown to be differentially expressed.
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