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公开(公告)号:US20140272998A1
公开(公告)日:2014-09-18
申请号:US14232806
申请日:2012-07-13
申请人: Ulrik Ralfkiaer , Peter Hagedorn , Charlotte Busch Ahler , Carsten Geisler , Anders Woetmann , Lone Skov , Niels Feentved Odum , Elisabeth Ralfkiaer
发明人: Ulrik Ralfkiaer , Peter Hagedorn , Charlotte Busch Ahler , Carsten Geisler , Anders Woetmann , Lone Skov , Niels Feentved Odum , Elisabeth Ralfkiaer
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要: The present invention relates to the field of cancer-diagnostics. In particular the invention relates to a microRNA expression signature that allows discriminating skin samples of cutaneous T-cell lymphomas (CTCL) from non-malignant (inflammantory) skin samples by use of quantitative polymerase chain reaction performed on reverse transcribed miRNA. miR-155, miR-326, miR-663b, miR-203 and miR-205 are shown to be differentially expressed.
摘要翻译: 本发明涉及癌症诊断领域。 特别地,本发明涉及通过使用对逆转录miRNA进行的定量聚合酶链反应,允许从非恶性(炎症性)皮肤样品鉴别皮肤T细胞淋巴瘤(CTCL)的皮肤样品的微小RNA表达特征。 miR-155,miR-326,miR-663b,miR-203和miR-205显示出差异表达。