发明申请
US20140275025A1 SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
有权
取代的2-AZA-BICYCLO [2.2.1]乙酰-3-羧酸（苄基 - 氰基 - 甲基） - CATHEPSIN C的胺抑制剂
![SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C](/docs/US/2014-09-18/US20140275025A1/abs.jpg.600x600.jpg)
- 专利标题： SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
- 专利标题（中）： 取代的2-AZA-BICYCLO [2.2.1]乙酰-3-羧酸（苄基 - 氰基 - 甲基） - CATHEPSIN C的胺抑制剂
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申请号： US14205861申请日： 2014-03-12
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公开(公告)号： US20140275025A1公开(公告)日： 2014-09-18
- 发明人: Ralf ANDERSKEWITZ , Florian BINDER , Matthias GRAUERT , Marc GRUNDL , Peter Wilhelm HAEBEL , Thorsten OOST , Alexander PAUTSCH , Stefan PETERS , Viktor VINTONYAK
- 申请人： Ralf ANDERSKEWITZ , Florian BINDER , Matthias GRAUERT , Marc GRUNDL , Peter Wilhelm HAEBEL , Thorsten OOST , Alexander PAUTSCH , Stefan PETERS , Viktor VINTONYAK
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： EP13159240.4 20130314; EP13170005.6 20130531
- 主分类号： C07D209/52
- IPC分类号： C07D209/52 ; A61K31/4035 ; A61K45/06 ; C07D405/12 ; A61K31/403 ; C07D401/12 ; A61K31/438 ; A61K31/496 ; A61K31/4045 ; C07D403/14 ; A61K31/4192 ; A61K31/4155 ; C07D498/04 ; A61K31/5383 ; A61K31/551 ; C07D487/10 ; C07D403/12
![SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C](/abs-image/US/2014/09/18/US20140275025A1/abs.jpg.150x150.jpg)
摘要：
This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid(benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
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