A structural assembly for use in building applications is disclosed. The assembly has spaced inner and outer face sheets, as well as one or more intermediate panels positioned between the inner and outer face sheets. The intermediate panels are parallel to the inner and outer face sheets, and are supported by alternating flanged web members that engage either the inner or outer face sheets. The assembly provides an enhanced ability to dissipate blast or projectile impact forces and to carry the forces throughout the assembly, thus maintaining sufficient structural integrity in the building to enable the occupants to evacuate, to enable contents to be evacuated, and to enable reuse of the building itself.