发明申请
- 专利标题: BIOCHIP SUBSTRATUM AND METHOD FOR PRODUCTION THEREOF
- 专利标题(中): 生物基质及其生产方法
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申请号: US14338205申请日: 2014-07-22
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公开(公告)号: US20140336081A1公开(公告)日: 2014-11-13
- 发明人: Kiyoshi NOKIHARA , Akiyoshi HIRATA , Yasuo OKA , Yasushi TAKEBAYASHI
- 申请人: HIPEP LABORATORIES , NIPPON LIGHT METAL COMPANY, LTD.
- 申请人地址: JP Tokyo JP Kyoto-shi
- 专利权人: NIPPON LIGHT METAL COMPANY, LTD.,HIPEP LABORATORIES
- 当前专利权人: NIPPON LIGHT METAL COMPANY, LTD.,HIPEP LABORATORIES
- 当前专利权人地址: JP Tokyo JP Kyoto-shi
- 优先权: JP2008-171322 20080630
- 主分类号: G01N33/545
- IPC分类号: G01N33/545 ; C08J3/28
摘要:
A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.
公开/授权文献
- US09857369B2 Biochip substratum and method for production thereof 公开/授权日:2018-01-02
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