公开(公告)号：US12103983B2

公开(公告)日：2024-10-01

申请号：US17299035

申请日：2019-10-31

申请人： HiPep Laboratories

发明人： Kiyoshi Nokihara ,  Yuki Tominaga ,  Atsushi Kitagawa ,  Shun Nokihara

IPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/64

CPC分类号： C07K7/06 ,  C07K7/64 ,  A61K38/00

摘要： Disclosed are a novel compound having a higher angiogenic effect than that of a known peptide-based angiogenic agent, and an angiogenic agent including the novel compound. The compound is represented by the following formula [1]: Cyclic(Cys-O2Oc-SVV(F/Y)GLRG-Cys)-NH2 (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), the following formula [II]: Cyclic(O2Oc-SVV(F/Y)GLRQ)-NH2 [II] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6), or the following formula [III]: O2Oc-SVV(F/Y)GLR-NH2 [III] (wherein the number of oxyethylene units, represented by O2Oc, is within the range of 2 to 6).

公开(公告)号：US09857369B2

公开(公告)日：2018-01-02

申请号：US14338205

申请日：2014-07-22

申请人： HIPEP LABORATORIES ,  NIPPON LIGHT METAL COMPANY, LTD.

发明人： Kiyoshi Nokihara ,  Akiyoshi Hirata ,  Yasuo Oka ,  Yasushi Takebayashi

IPC分类号： G01N33/545 ,  C12Q1/68 ,  G01N33/543 ,  C08J3/28 ,  B01L3/00

CPC分类号： G01N33/545 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01L3/50 ,  C08J3/28 ,  C12Q1/6837 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/273

摘要： A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.

公开(公告)号：US20140336081A1

公开(公告)日：2014-11-13

申请号：US14338205

申请日：2014-07-22

申请人： HIPEP LABORATORIES ,  NIPPON LIGHT METAL COMPANY, LTD.

发明人： Kiyoshi NOKIHARA ,  Akiyoshi HIRATA ,  Yasuo OKA ,  Yasushi TAKEBAYASHI

IPC分类号： G01N33/545 ,  C08J3/28

CPC分类号： G01N33/545 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01L3/50 ,  C08J3/28 ,  C12Q1/6837 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/273

摘要： A substrate for biochips which has a high probe loading amounts and a uniform immobilization density, and which further has a high detection sensitivity and a high reproducibility by preventing a non-specific adsorption of proteins, when used as a substrate for biochips for immobilizing probes composed of biologically relevant substances such as proteins and nucleic acids, is disclosed. Amino groups can be bound to the surface of the substrate uniformly, at a high density and stably by covalently immobilizing an amino group-containing polymer on the surface of the substrate. The probe immobilization rate is high and immobilizing density was uniform by immobilizing a probe composed of a biologically relevant substance such as a protein or nucleic acid by utilizing the amino groups. Further, detection sensitivity and reproducibility are high by inhibiting non-specific adsorption of proteins.

摘要翻译： 用于生物芯片的基底，其具有高的探针加载量和均匀的固定密度，并且当用作用于固定探针的生物芯片的基底时，通过防止蛋白质的非特异性吸附进一步具有高检测灵敏度和高重现性 的生物相关物质，如蛋白质和核酸。 通过将含氨基的聚合物共价固定在基材的表面上，氨基可以均匀地以高密度和稳定地结合到基材的表面。 探针固定率高，固定化密度均匀，通过利用氨基固定由生物相关物质如蛋白质或核酸组成的探针。 此外，通过抑制蛋白质的非特异性吸附，检测灵敏度和再现性高。