发明申请
US20140350113A1 CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF
有权
HIV-1入侵的CD4-物质抑制剂及其使用方法
- 专利标题： CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF
- 专利标题（中）： HIV-1入侵的CD4-物质抑制剂及其使用方法
-
申请号： US14365389申请日： 2012-12-14
-
公开(公告)号： US20140350113A1公开(公告)日： 2014-11-27
- 发明人: Joseph Sodroski , Judith M. LaLonde , Amos B. Smith, III , Peter D. Kwong , Young Do Kwon , David M. Jones , Alexander W. Sun , Joel R. Courter , Takahiro Soeta , Toyoharu Kobayashi , Amy M. Princiotto , Xueling Wu , John R. Mascola , Ame Schon , Emesto Freire , Navid Madani , Matthew Le-Khac , Wayne A. Hendrickson
- 申请人： Dana-Farber Cancer Institute, Inc. , The Trustees of the University of Pennsylvania , United States of Americas as Represented By The Secretary, Department of Health and Human Services , Bryn Mawr College , The Johns Hopkins University , The Trustees of Columbia University in the City of New York
- 国际申请： PCT/US12/69708 WO 20121214
- 主分类号： C07C279/16
- IPC分类号： C07C279/16 ; C07C237/06
摘要：
Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556.
公开/授权文献
信息查询
