Invention Application
- Patent Title: METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS
- Patent Title (中): 确定镜片上羧基组合物表面浓度的方法
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Application No.: US14289046Application Date: 2014-05-28
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Publication No.: US20140356965A1Publication Date: 2014-12-04
- Inventor: Xinming Qian , Frank Chang , Troy Vernon Holland , Yongxing Qiu , Venkat Shankar
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Main IPC: G01N33/44
- IPC: G01N33/44

Abstract:
The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.
Public/Granted literature
- US09950483B2 Method for determining the surface concentration of carboxyl groups on a lens Public/Granted day:2018-04-24
Information query