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    Process for producing contact lenses with durable lubricious coatings thereon
    1.
    发明授权
    Process for producing contact lenses with durable lubricious coatings thereon 有权

    公开(公告)号：US11385478B2

    公开(公告)日：2022-07-12

    申请号：US15704233

    申请日：2017-09-14

    申请人： Novartis AG

    发明人： Yongxing Qiu ,  John Dallas Pruitt ,  Kelly Kayi Tallau ,  Angela Driver-Scott ,  Chung-Yuan Chiang

    IPC分类号： G02C7/04 ,  B29D11/00 ,  G02B1/14 ,  C09D133/02 ,  C09D177/06 ,  G02B1/04

    摘要： The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon. This method has a minimized adverse impact on the mechanical properties of silicone hydrogel lens body.

    Hydrogel contact lenses with lubricious coating thereon
    2.
    发明授权
    Hydrogel contact lenses with lubricious coating thereon 有权

    公开(公告)号：US10449739B2

    公开(公告)日：2019-10-22

    申请号：US15704205

    申请日：2017-09-14

    申请人： Novartis AG

    发明人： Yongxing Qiu ,  John Dallas Pruitt ,  Jared Nelson

    IPC分类号： B29D11/00 ,  C08F20/00 ,  G02B1/04 ,  C08F220/20 ,  C08F220/58

    摘要： The invention is generally related to soft contact lenses which comprise a non-silicone hydrogel lens body and a hydrogel coating thereon. The non-silicone hydrogel lens body is composed of a hydrogel material which is free of silicone and comprises at least 50% by mole of repeating units of at least one hydroxyl-containing vinylic monomer. The hydrogel coating comprises a first polymeric material having first reactive functional groups and a hydrogel layer derived from a second polymeric material having second reactive functional groups, and the hydrogel layer is covalently attached onto the anchor layer through linkages each formed between one first reactive functional group and one second reactive functional group. The soft contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and has a friction rating of about 2 or lower after 7 cycles of manual rubbing, a water content of from about 10% to about 85% by weight and an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated at room temperature.

    Method for determining the surface concentration of carboxyl groups on a lens
    5.
    发明授权
    Method for determining the surface concentration of carboxyl groups on a lens 有权

    公开(公告)号：US09950483B2

    公开(公告)日：2018-04-24

    申请号：US14289046

    申请日：2014-05-28

    申请人： Novartis AG

    发明人： Xinming Qian ,  Frank Chang ,  Troy Vernon Holland ,  Yongxing Qiu ,  Venkat Shankar

    IPC分类号： G02B1/04 ,  C23C14/54 ,  C23C16/52 ,  B29D11/00

    CPC分类号： B29D11/00865 ,  B29D11/00951 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14 ,  C08L33/26

    摘要： The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.

    HYDROGEL CONTACT LENSES WITH LUBRICIOUS COATING THEREON
    6.
    发明申请
    HYDROGEL CONTACT LENSES WITH LUBRICIOUS COATING THEREON 审中-公开

    公开(公告)号：US20180079158A1

    公开(公告)日：2018-03-22

    申请号：US15704205

    申请日：2017-09-14

    申请人： Novartis AG

    发明人： Yongxing Qiu ,  John Dallas Pruitt ,  Jared Nelson

    IPC分类号： B29D11/00 ,  G02B1/04 ,  C08F20/00

    CPC分类号： B29D11/00067 ,  B29D11/00038 ,  B29D11/00865 ,  B29D11/00923 ,  B29K2995/0092 ,  C08F20/00 ,  C08F220/20 ,  C08F220/58 ,  G02B1/043

    摘要： The invention is generally related to soft contact lenses which comprise a non-silicone hydrogel lens body and a hydrogel coating thereon. The non-silicone hydrogel lens body is composed of a hydrogel material which is free of silicone and comprises at least 50% by mole of repeating units of at least one hydroxyl-containing vinylic monomer. The hydrogel coating comprises a first polymeric material having first reactive functional groups and a hydrogel layer derived from a second polymeric material having second reactive functional groups, and the hydrogel layer is covalently attached onto the anchor layer through linkages each formed between one first reactive functional group and one second reactive functional group. The soft contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and has a friction rating of about 2 or lower after 7 cycles of manual rubbing, a water content of from about 10% to about 85% by weight and an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated at room temperature.

    COLORED HYDROGEL CONTACT LENSES WITH LUBRICIOUS COATING THEREON
    7.
    发明申请
    COLORED HYDROGEL CONTACT LENSES WITH LUBRICIOUS COATING THEREON 审中-公开

    公开(公告)号：US20180079157A1

    公开(公告)日：2018-03-22

    申请号：US15704188

    申请日：2017-09-14

    申请人： Novartis AG

    发明人： Robert Carey Tucker ,  John Dallas Pruitt ,  Yongxing Qiu

    IPC分类号： B29D11/00 ,  G02C7/02 ,  G02B1/04 ,  C09D177/00

    摘要： The invention is generally related to colored contact lenses which comprise a hydrogel lens body having an opaque color image therein and/or thereon and a durable lubricious coating thereon. The coating comprises an anchoring layer of a polyanionic polymer having carboxyl groups and a hydrogel layer which is derived from a hydrophilic polymeric material having azetidinium groups and is covalently attached onto the anchoring layer of the polyanionic polymer through linkages each formed between one carboxyl group and one azetidinium groups. The colored contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and a friction rating of about 2 or lower after 7 cycles of manual rubbing.

    Method for applying a coating onto a silicone hydrogel lens
    8.
    发明授权
    Method for applying a coating onto a silicone hydrogel lens 有权
    将涂层涂布在硅酮水凝胶镜片上的方法

    公开(公告)号：US09575332B2

    公开(公告)日：2017-02-21

    申请号：US14101640

    申请日：2013-12-10

    申请人： Novartis AG

    发明人： Yongxing Qiu ,  Arturo Norberto Medina ,  John Dallas Pruitt

    IPC分类号： G02B1/04 ,  B29D11/00 ,  B65B25/00 ,  G02C7/04 ,  B65B55/02

    CPC分类号： G02C7/04 ,  B29D11/00865 ,  B65B55/02 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

    摘要： The present invention generally relates to a method for applying a coating of hydrophilic polymers onto silicone hydrogel contact lenses to improve hydrophilicity and lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant silicone hydrogel contact lens has a coating with good hydrophilicity, improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rising.

    摘要翻译： 本发明一般涉及将亲水性聚合物涂层涂覆在硅氧水凝胶隐形眼镜上以改善亲水性和润滑性的方法。 特别地，本发明涉及一种在初级包装中直接形成隐形眼镜，优选硅酮水凝胶隐形眼镜上的涂层的方法，并将涂覆的隐形眼镜保持在所述初级包装内，直到将涂覆的隐形眼镜插入 隐形眼镜用户的眼睛。 所得的硅酮水凝胶隐形眼镜具有亲水性好，润滑性好，耐久性好的涂层，也可以由患者直接从镜片包装中使用而无需洗涤和/或上升。