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    CAST-MOLDING PROCESS FOR PRODUCING UV-ABSORBING CONTACT LENSES
    1.
    发明申请
    CAST-MOLDING PROCESS FOR PRODUCING UV-ABSORBING CONTACT LENSES 审中-公开

    公开(公告)号：US20190225726A1

    公开(公告)日：2019-07-25

    申请号：US16250003

    申请日：2019-01-17

    Applicant: Novartis AG

    Inventor： Ryan DeSousa ,  Troy Vernon Holland ,  Frank Chang

    IPC: C08F216/06 ,  B29D11/00 ,  B29C35/08 ,  C08K5/17 ,  C08K5/3435 ,  C08J3/24 ,  C08L29/06 ,  C08L83/04

    Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively-short curing time from a lens-forming composition, which comprises (a) at least one thiol-containing compound or component, (b) at least one metal scavenger, and (c) at least one free radical scavenger and which has a pH of from about 2.5 to about 5. The addition of a chain-transfer agent into a lens-forming composition can reduce not only the curing time of the lens-forming composition but also reduce the elastic modulus of resultant crosslinked materials (e.g., contact lenses) from the lens-forming composition. The lower pH and the addition of metal scavenger and the free radical scavenger into the lens-forming composition can ensure that the lens-forming composition to have a shelf life of at least three days.

    Chain-extended polydimethylsiloxane vinylic crosslinkers and uses thereof
    4.
    发明授权
    Chain-extended polydimethylsiloxane vinylic crosslinkers and uses thereof 有权

    公开(公告)号：US10301451B2

    公开(公告)日：2019-05-28

    申请号：US15727666

    申请日：2017-10-09

    Applicant: Novartis AG

    Inventor： Feng Jing ,  Frank Chang

    IPC: C08G77/14 ,  C08K5/00 ,  C08K5/5419 ,  C08G77/20 ,  C08G77/392 ,  C08G77/38 ,  C08G77/388 ,  G02C7/04

    Abstract: The invention provides a chain-extended polydiorganosiloxane vinylic crosslinker which comprises (1) a polymer chain comprising at least two polydiorganosiloxane segments and one hydrophilized linker between each pair of polydiorganosiloxane segements, wherein each polydiorganosiloxane comprises at least 5 dimethylsiloxane units in a consecutive sequence, wherein the hydrophilized linker is a divalent radical having at least two (meth)acrylamide moieties; (2) two terminal (meth)acryloyl groups, wherein the chain-extended polydiorganosiloxane vinylic crosslinker has an average molecular weight of at least about 1500 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a chain-extended polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising a chain-extended polydiorganosiloxane vinylic crosslinker of the invention.

    POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS
    5.
    发明申请
    POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS 审中-公开

    公开(公告)号：US20190153141A1

    公开(公告)日：2019-05-23

    申请号：US16255043

    申请日：2019-01-23

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Ryan DeSousa ,  Jinyu Huang

    IPC: C08F290/06 ,  C08G77/38 ,  C08G77/14 ,  G02B1/04 ,  C08G77/20

    CPC classification number: C08F290/068 ,  C08G77/12 ,  C08G77/14 ,  C08G77/20 ,  C08G77/38 ,  C08G2210/00 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04

    Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

    Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof
    6.
    发明授权
    Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof 有权

    公开(公告)号：US10246543B2

    公开(公告)日：2019-04-02

    申请号：US16110194

    申请日：2018-08-23

    Applicant: Novartis AG

    Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

    IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  C08G77/20 ,  C08G77/16 ,  C08G77/392 ,  G02B1/04 ,  C08G77/12

    Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

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