Invention Application
- Patent Title: CHROMAN DERIVATIVES AS TRPM8 INHIBITORS
- Patent Title (中): CHROMAN DERIVATIVES作为TRPM8抑制剂
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Application No.: US14331426Application Date: 2014-07-15
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Publication No.: US20150031668A1Publication Date: 2015-01-29
- Inventor: Kaustav Biswas , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma , Kelvin Sham , James Brown , Wenge Zhong , Thomas T. Nguyen
- Applicant: AMGEN INC.
- Main IPC: C07D491/052
- IPC: C07D491/052 ; C07D498/04 ; C07D471/04
Abstract:
Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Information query
