发明申请
- 专利标题： CHROMAN DERIVATIVES AS TRPM8 INHIBITORS
- 专利标题（中）： CHROMAN DERIVATIVES作为TRPM8抑制剂
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申请号： US14331426申请日： 2014-07-15
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公开(公告)号： US20150031668A1公开(公告)日： 2015-01-29
- 发明人: Kaustav Biswas , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma , Kelvin Sham , James Brown , Wenge Zhong , Thomas T. Nguyen
- 申请人： AMGEN INC.
- 主分类号： C07D491/052
- IPC分类号： C07D491/052 ; C07D498/04 ; C07D471/04
摘要：
Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
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