专利检索 ap:("AMGEN INC.") AND inv:"Matthew R. Kaller" 第 1 页

1.

发明授权
Heteroaryl-substituted triazoles as APJ receptor agonists 有权

公开(公告)号：US11046680B1

公开(公告)日：2021-06-29

申请号：US16347910

申请日：2017-11-03

申请人： AMGEN INC.

发明人： Ning Chen , Xiaoqi Chen , Yinhong Chen , Alan C. Cheng , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , James S. Harvey , Julie Anne Heath , Lars V. Heumann , Daniel B. Horne , Jonathan Houze , Matthew R. Kaller , Frank Kayser , Aarif Yusuf Khakoo , David J. Kopecky , Su-Jen Lai , Zhihua Ma , Julio C. Medina , Jeffrey T. Mihalic , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Malgorzata Wanska , Kevin Yang , Wen-Chen Yeh

IPC分类号： C07D417/14 , A61P9/00 , C07D401/14 , C07D403/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04

摘要： Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

2.

发明授权
Intermediates for preparing triazole agonists of the APJ receptor 有权

公开(公告)号：US09656998B2

公开(公告)日：2017-05-23

申请号：US15298686

申请日：2016-10-20

申请人： AMGEN INC.

发明人： Ning Chen , Xiaoqi Chen , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , Julie Anne Heath , Daniel B. Horne , Jonathan Houze , Matthew R. Kaller , David John Kopecky , Su-Jen Lai , Zhihua Ma , Lawrence R. McGee , Julio C. Medina , Jeffrey T. Mihalic , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Xiaodong Wang , Kevin Yang , Mikkel V. Debenedetto , Robert P. Farrell , Simon J. Hedley , Ted C. Judd

IPC分类号： C07D213/82 , C07D241/24 , C07D401/12 , C07D401/14 , C07D401/04 , C07D413/04 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K45/06 , C07B57/00 , C07B59/00 , C07D211/54 , C07D213/71 , C07D239/26 , C07D239/30 , C07D241/12 , C07D249/08 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/695

CPC分类号： A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08

摘要： Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers are useful intermediates in the synthesis of agonists of the APJ Receptor. Compounds of Formula V have the following structure: where the definitions of the variables are provided herein.

3.

发明申请
AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS 有权
标题翻译：阿司匹林和哌啶化合物作为PDE10抑制剂有用

公开(公告)号：US20130338138A1

公开(公告)日：2013-12-19

申请号：US13917699

申请日：2013-06-14

申请人： AMGEN INC.

发明人： Jennifer R. Allen , Jian J. Chen , Michael J. Frohn , Matthew R. Kaller , Qingyian Liu , Thomas T. Nguyen , Alexander J. Pickrell , Wenyuan Qian , Robert M. Rzasa , Wenge Zhong

IPC分类号： C07D401/14 , C07D471/04 , A61K31/517 , A61K31/497 , A61K45/06

CPC分类号： C07D471/04 , A61K31/497 , A61K31/517 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14

摘要： Azetidine and piperidine compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds and intermediates thereof. Provided herein also are methods of treating cognitive disorders or diseases treatable by inhibition of PDE10, such as Huntington's Disease, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 式（I）的氮杂环丁烷和哌啶化合物：如说明书中所定义，含有它们的组合物，以及制备这些化合物的方法及其中间体。本文还提供治疗认知障碍或通过抑制PDE10可治疗的疾病的方法，例如亨廷顿舞蹈病，精神分裂症，双相障碍，强迫症等。

4.

发明申请
COMPOUNDS THAT INHIBIT MCL-1 PROTEIN 审中-公开

公开(公告)号：US20180289720A1

公开(公告)日：2018-10-11

申请号：US15938001

申请日：2018-03-28

申请人： AMGEN INC.

发明人： Paul E. Harrington , Kate Ashton , Sean P. Brown , Matthew R. Kaller , Todd J. Kohn , Brian Alan Lanman , Kexue Li , Yunxiao Li , Jonathan D. Low , Ana Elena Minatti , Alexander J. Pickrell , Markian M. Stec , Joshua Taygerly

IPC分类号： A61K31/553 , A61P35/00

CPC分类号： A61K31/553 , A61P35/00 , A61P35/02 , C07D498/08

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

5.

发明申请
TRIAZOLE AGONISTS OF THE APJ RECEPTOR 有权
标题翻译： APJ受体的三唑激动剂

公开(公告)号：US20160340336A1

公开(公告)日：2016-11-24

申请号：US15158174

申请日：2016-05-18

申请人： AMGEN INC.

发明人： Ning Chen , Xiaoqi Chen , Yinhong Chen , Alan C. Cheng , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , Julie Anne Heath , Daniel B. Horne , Jonathan Houze , Matthew R. Kaller , Aarif Yusuf Khakoo , David John Kopecky , Su-Jen Lai , Zhihua Ma , Lawrence R. McGee , Julio C. Medina , Jeffrey T. Mihalic , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Kevin Yang , Wen-Chen Yeh , Mikkel V. Debenedetto , Robert P. Farrell , Simon J. Hedley , Ted C. Judd , Frank Kayser

IPC分类号： C07D401/14 , C07D213/82 , C07D241/24 , C07D239/30 , C07D239/26 , C07D401/04 , A61K31/4439 , A61K31/506 , C07D413/14 , C07B59/00 , A61K31/497 , A61K31/513 , C07D471/04 , A61K31/444 , C07D417/14 , C07B57/00 , C07D405/14 , A61K31/501 , C07D249/08 , C07D241/12 , C07D213/71 , C07D211/54 , A61K45/06

CPC分类号： A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08

摘要： Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

摘要翻译： 其中在这里提供变量的定义。

6.

发明授权
Azetidine and piperidine compounds useful as PDE10 inhibitors 有权
标题翻译：可用作PDE10抑制剂的氮杂环丁烷和哌啶化合物

公开(公告)号：US09493459B2

公开(公告)日：2016-11-15

申请号：US15058023

申请日：2016-03-01

申请人： AMGEN INC.

发明人： Jennifer R. Allen , Jian J. Chen , Michael J. Frohn , Matthew R. Kaller , Qingyian Liu , Thomas T. Nguyen , Alexander J. Pickrell , Wenyuan Qian , Robert M. Rzasa , Wenge Zhong

IPC分类号： C07D401/04 , C07D403/04 , C07D471/04 , C07D401/14 , A61K31/497 , A61K45/06 , A61K31/517 , C07D403/14

CPC分类号： C07D471/04 , A61K31/497 , A61K31/517 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14

摘要： Azetidine and piperidine compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds and intermediates thereof. Provided herein also are methods of treating cognitive disorders or diseases treatable by inhibition of PDE10, such as Huntington's Disease, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

7.

发明授权
TRPM8 antagonists and their use in treatments 有权
标题翻译： TRPM8拮抗剂及其在治疗中的应用

公开(公告)号：US09096527B2

公开(公告)日：2015-08-04

申请号：US14187677

申请日：2014-02-24

申请人： AMGEN INC.

发明人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, Jr. , Chester Chenguang Yuan , Wenge Zhong

IPC分类号： C07D498/04 , C07D401/12 , C07D471/04 , C07D213/81 , C07D213/82 , C07D213/40 , C07D213/61 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04

CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04

摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

摘要翻译： 式I的化合物可用作TRPM8的拮抗剂。这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。这些疾病的实例包括但不限于偏头痛和神经性疼痛。式I的化合物具有以下结构：其中本文提供变量的定义。

8.

发明授权
Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors 有权
标题翻译：吡啶和嘧啶衍生物作为磷酸二酯酶10抑制剂

公开(公告)号：US08759532B2

公开(公告)日：2014-06-24

申请号：US13676826

申请日：2012-11-14

申请人： AMGEN Inc.

发明人： Jennifer R. Allen , Kaustav Biswas , Frank Chavez, Jr. , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Home , Essa Hu Harrington , Matthew R. Kaller , Roxanne K. Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao

IPC分类号： C07D239/02 , A61K31/397

CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , C07D473/00

摘要： Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖型糖尿病，精神分裂症，双相情感障碍，强迫症等。