发明申请
- 专利标题： BLOCK COPOLYMER HAVING PHENYLBORONIC ACID GROUP INTRODUCED THEREIN, AND USE THEREOF
- 专利标题（中）： 含有苯乙酸的嵌段共聚物及其用途
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申请号： US14358816申请日： 2012-11-19
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公开(公告)号： US20150051347A1公开(公告)日： 2015-02-19
- 发明人: Kazunori Kataoka , Takehiko Ishii , Mitsuru Naito , Akira Matsumoto , Yasuki Kato
- 申请人： THE UNIVERSITY OF TOKYO , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , NanoCarrier Co., Ltd.
- 申请人地址： JP Tokyo JP Tokyo JP Kashiwa-shi
- 专利权人： THE UNIVERSITY OF TOKYO,NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY,NANOCARRIER CO., LTD.
- 当前专利权人： THE UNIVERSITY OF TOKYO,NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY,NANOCARRIER CO., LTD.
- 当前专利权人地址： JP Tokyo JP Tokyo JP Kashiwa-shi
- 国际申请： PCT/JP2012/079897 WO 20121119
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K31/713 ; C08G81/00
摘要：
A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.