摘要:
A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.
摘要:
A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.
摘要:
An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.
摘要:
A modified nanoparticle includes a nanoparticle, a dispersibility improving group bound to a surface of the nanoparticle, and an oligosaccharide that is bound to the surface of the nanoparticle, and that selectively captures a specific virus or bacterium. A reagent for detection of a specific virus or bacterium by resistive pulse sensing is also provided, the reagent including the modified nanoparticle.