Invention Application
- Patent Title: Environmentally Responsive Microstructured Hybrid Actuator Assemblies For Use in Mechanical Stimulation of Cells
- Patent Title (中): 用于机械刺激细胞的环境微结构混合致动器组件
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Application No.: US14094152Application Date: 2013-12-02
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Publication No.: US20150093823A1Publication Date: 2015-04-02
- Inventor: Amy Alexandra SUTTON , Tanya SHIRMAN , Joanna AIZENBERG , Lauren ZARZAR , Philseok KIM
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee Address: US MA Cambridge
- Main IPC: C12M1/42
- IPC: C12M1/42 ; C12M1/12
Abstract:
A method for mechanical stimulation of cells includes providing a substrate comprising a plurality of microactuators embedded in an environmentally responsive hydrogel polymer layer disposed on a region of the surface; adhering at least one cell to the substrate; and exposing the environmentally responsive hydrogel polymer layer to a stimulus, the stimulus changing a volume of the environmentally responsive hydrogel polymer layer from a first volume to a second volume and thereby moving the microactuators from a first position to a second position, wherein the movement of the microactuators provides localized mechanical force directly to cells on the substrate.
Information query
