Environmentally Responsive Microstructured Hybrid Actuator Assemblies For Use in Mechanical Stimulation of Cells
    10.
    发明申请
    Environmentally Responsive Microstructured Hybrid Actuator Assemblies For Use in Mechanical Stimulation of Cells 审中-公开
    用于机械刺激细胞的环境微结构混合致动器组件

    公开(公告)号:US20150093823A1

    公开(公告)日:2015-04-02

    申请号:US14094152

    申请日:2013-12-02

    IPC分类号: C12M1/42 C12M1/12

    CPC分类号: C12M35/04 C12M25/02

    摘要: A method for mechanical stimulation of cells includes providing a substrate comprising a plurality of microactuators embedded in an environmentally responsive hydrogel polymer layer disposed on a region of the surface; adhering at least one cell to the substrate; and exposing the environmentally responsive hydrogel polymer layer to a stimulus, the stimulus changing a volume of the environmentally responsive hydrogel polymer layer from a first volume to a second volume and thereby moving the microactuators from a first position to a second position, wherein the movement of the microactuators provides localized mechanical force directly to cells on the substrate.

    摘要翻译: 用于机械刺激细胞的方法包括提供包含嵌入在表面区域上的环境响应性水凝胶聚合物层中的多个微致动器的基底; 将至少一个电池附着在基板上; 以及将所述环境响应性水凝胶聚合物层暴露于刺激,所述刺激将环境响应性水凝胶聚合物层的体积从第一体积改变到第二体积,从而将微致动器从第一位置移动到第二位置,其中, 微致动器直接向基板上的单元提供局部机械力。