发明申请
US20150105384A1 PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS
有权
哌嗪类羟基化合物作为脱乙酰壳多糖酶抑制剂
- 专利标题: PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS
- 专利标题(中): 哌嗪类羟基化合物作为脱乙酰壳多糖酶抑制剂
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申请号: US14510711申请日: 2014-10-09
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公开(公告)号: US20150105384A1公开(公告)日: 2015-04-16
- 发明人: Simon Stewart Jones , Min Yang , David Lee Tamang
- 申请人: Simon Stewart Jones , Min Yang , David Lee Tamang
- 申请人地址: US MA Boston
- 专利权人: Acetylon Pharmaceuticals, Inc.
- 当前专利权人: Acetylon Pharmaceuticals, Inc.
- 当前专利权人地址: US MA Boston
- 主分类号: C07D417/12
- IPC分类号: C07D417/12 ; C07D401/14 ; C07D239/42 ; C07D401/12
摘要:
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDAC1, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.
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