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1.发明申请COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND IMMUNOMODULATORY DRUGS 审中-公开组织脱乙酰壳多糖酶抑制剂和免疫调节剂的组合公开(公告)号：US20150105358A1
公开(公告)日：2015-04-16
申请号：US14508072
申请日：2014-10-07
IPC分类号： A61K31/505 , C07D401/04 , C07D239/42 , A61K31/454 , A61K31/573
CPC分类号： A61K31/505 , A61K31/454 , A61K31/573 , C07D239/42 , C07D401/04 , A61K2300/00
摘要： The invention relates to combinations comprising an HDAC inhibitor and an immunomodulatory drug for the treatment of multiple myeloma in a subject in need thereof. The combinations may, optionally, further comprise an anti-inflammatory agent, such as dexamethasone. Also provided herein are methods for treating multiple myeloma in a subject in need thereof comprising administering to the subject an effective amount of one of the above combinations.
摘要翻译： 本发明涉及包含HDAC抑制剂和用于在有需要的受试者中治疗多发性骨髓瘤的免疫调节药物的组合。 组合可以任选地进一步包含抗炎剂，例如地塞米松。 本文还提供了在有需要的受试者中治疗多发性骨髓瘤的方法，包括向受试者施用有效量的上述组合之一。
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2.发明申请HDAC INHIBITORS, ALONE OR IN COMBINATION WITH BTK INHIBITORS, FOR TREATING NONHODGKIN'S LYMPHOMA 审中-公开HDAC抑制剂，单独或与BTK抑制剂组合，用于治疗非霍奇金淋巴瘤公开(公告)号：US20150105409A1
公开(公告)日：2015-04-16
申请号：US14508135
申请日：2014-10-07
申请人： Steven Norman Quayle , Simon Stewart Jones , Eduardo M. Sotomayor , Javier Pinilla-Ibarz , Eva Sahakian
发明人： Steven Norman Quayle , Simon Stewart Jones , Eduardo M. Sotomayor , Javier Pinilla-Ibarz , Eva Sahakian
IPC分类号： C07D239/42 , A61K31/519 , A61K31/505
CPC分类号： C07D239/42 , A61K31/505 , A61K31/519 , A61K2300/00
摘要： The invention relates to HDAC inhibitors, or combinations comprising an HDAC inhibitor and a BTK inhibitor for the treatment of non-hodgkin's lymphoma in a subject in need thereof. Also provided herein are methods for treating non-hodgkin's lymphoma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor, or a combination comprising an HDAC inhibitor and a BTK inhibitor.
摘要翻译： 本发明涉及HDAC抑制剂或包含HDAC抑制剂和BTK抑制剂的组合物，用于在有需要的受试者中治疗非霍奇金淋巴瘤。 本文还提供了在有需要的受试者中治疗非霍奇金淋巴瘤的方法，包括向受试者施用治疗有效量的HDAC抑制剂或包含HDAC抑制剂和BTK抑制剂的组合。
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3.发明申请公开(公告)号：US20150105384A1
公开(公告)日：2015-04-16
申请号：US14510711
申请日：2014-10-09
申请人： Simon Stewart Jones , Min Yang , David Lee Tamang
发明人： Simon Stewart Jones , Min Yang , David Lee Tamang
IPC分类号： C07D417/12 , C07D401/14 , C07D239/42 , C07D401/12
CPC分类号： A61K31/506 , A61K31/505 , A61K31/5377 , A61K45/06 , C07D239/42 , C07D401/12 , C07D401/14 , C07D417/12
摘要： Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity, particularly diseases or disorders that involve activity of HDAC1, HDAC2, and/or HDAC6. Also provided herein are methods for inhibiting migration of a neuroblastoma cell, inducing maturation of a neuroblastoma cell, and altering cell cycle progression of a neuroblastoma cell comprising administering to the cell a therapeutically effective amount of a HDAC1, HDAC2, and/or HDAC6 selective inhibitor or a pharmaceutically acceptable salt thereof.
摘要翻译： 本文提供了化合物，包含这些化合物的药物组合物，以及使用这些化合物治疗或预防与HDAC活性有关的疾病或病症的方法，特别是涉及HDAC1，HDAC2和/或HDAC6的活性的疾病或病症。 本文还提供了抑制成神经细胞瘤细胞迁移的方法，诱导神经母细胞瘤细胞的成熟和改变神经母细胞瘤细胞的细胞周期进程，包括向细胞施用治疗有效量的HDAC1，HDAC2和/或HDAC6选择性抑制剂 或其药学上可接受的盐。
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4.发明申请HDAC Inhibitors, Alone Or In Combination With PI3K Inhibitors, For Treating Non-Hodgkin's Lymphoma 审中-公开HDAC抑制剂，单独或与PI3K抑制剂组合，用于治疗非霍奇金淋巴瘤公开(公告)号：US20150105383A1
公开(公告)日：2015-04-16
申请号：US14509360
申请日：2014-10-08
IPC分类号： C07D239/42 , A61K31/5377 , A61K31/52 , A61K31/505
CPC分类号： C07D239/42 , A61K31/505 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The invention relates to HDAC inhibitors, or combinations comprising an HDAC inhibitor and a PI3K inhibitor for the treatment of non-hodgkin's lymphoma in a subject in need thereof. Also provided herein are methods for treating non-hodgkin's lymphoma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor, or a combination comprising an HDAC inhibitor and a PI3K inhibitor.
摘要翻译： 本发明涉及HDAC抑制剂或包含HDAC抑制剂和PI3K抑制剂的组合，用于治疗有需要的受试者中的非霍奇金淋巴瘤。 本文还提供了在有需要的受试者中治疗非霍奇金淋巴瘤的方法，包括向受试者施用治疗有效量的HDAC抑制剂或包含HDAC抑制剂和PI3K抑制剂的组合。
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