发明申请
- 专利标题： COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
- 专利标题（中）： 作为蛋白激酶抑制剂的化合物和组合物
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申请号： US14574063申请日： 2014-12-17
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公开(公告)号： US20150105390A1公开(公告)日： 2015-04-16
- 发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
- 申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
- 申请人地址： BM Hamilton
- 专利权人： IRM LLC, a Delaware Limited Liability Company
- 当前专利权人： IRM LLC, a Delaware Limited Liability Company
- 当前专利权人地址： BM Hamilton
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61K45/06 ; A61K31/5377 ; C07D239/48 ; C07D401/14 ; C07D401/12
摘要：
The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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