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公开(公告)号:US20150105390A1
公开(公告)日:2015-04-16
申请号:US14574063
申请日:2014-12-17
申请人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号: A61K31/506 , A61K45/06 , A61K31/5377 , C07D239/48 , C07D401/14 , C07D401/12
CPC分类号: A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要: The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译: 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物,以及使用这些化合物的方法。 例如,本发明的嘧啶和吡啶衍生物可用于治疗,改善或预防响应于间变性淋巴瘤激酶(ALK)活性,粘着斑激酶(FAK),ζ-链相关蛋白激酶70 (ZAP-70),胰岛素样生长因子(IGF-1R)或其组合。
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公开(公告)号:US08957081B2
公开(公告)日:2015-02-17
申请号:US13610422
申请日:2012-09-11
申请人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号: A61K31/519 , A61K31/52 , A61K31/517 , C07D239/02 , C07D239/42 , C07D403/12 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
CPC分类号: A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要: The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译: 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物,以及使用这些化合物的方法。 例如,本发明的嘧啶和吡啶衍生物可用于治疗,改善或预防响应于间变性淋巴瘤激酶(ALK)活性,粘着斑激酶(FAK),ζ-链相关蛋白激酶70 (ZAP-70),胰岛素样生长因子(IGF-1R)或其组合。
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公开(公告)号:US20110257154A1
公开(公告)日:2011-10-20
申请号:US13172357
申请日:2011-06-29
申请人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号: A61K31/397 , A61K31/506 , C07D239/48 , A61K31/505 , C07D413/14 , A61K31/5377 , C07D413/12 , C07D403/12 , A61K31/496 , C07D487/04 , A61K31/519 , A61K31/52 , A61P31/00 , A61P35/00 , C12N5/09 , C07D401/14
CPC分类号: A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要: The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号:US08399450B2
公开(公告)日:2013-03-19
申请号:US13172357
申请日:2011-06-29
申请人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号: A61K31/4164 , A61K31/535 , A61K31/497 , A61K31/505 , C07D413/12 , C07D403/12 , C07D239/02
CPC分类号: A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要: The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号:US20080176881A1
公开(公告)日:2008-07-24
申请号:US11943436
申请日:2007-11-20
申请人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号: A61K31/505 , C07D239/48 , C12N9/99 , C07D213/38 , A61P35/00
CPC分类号: A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要: The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译: 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物,以及使用这些化合物的方法。 例如,本发明的嘧啶和吡啶衍生物可用于治疗,改善或预防响应于间变性淋巴瘤激酶(ALK)活性,粘着斑激酶(FAK),ζ-链相关蛋白激酶70 (ZAP-70),胰岛素样生长因子(IGF-1R)或其组合。
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公开(公告)号:US20130005748A1
公开(公告)日:2013-01-03
申请号:US13610422
申请日:2012-09-11
申请人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号: A61K31/519 , A61P31/00 , A61P35/00 , A61P37/06 , A61K31/52 , A61K31/517
CPC分类号: A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要: The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号:US20110190259A1
公开(公告)日:2011-08-04
申请号:US13048636
申请日:2011-03-15
申请人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号: A61K31/506 , C07D401/14 , C12N9/99 , C07D239/24 , C07D413/14 , A61K31/5377 , C07D403/02 , A61P25/00 , A61P37/06
CPC分类号: A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要: The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译: 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物,以及使用这些化合物的方法。 例如,本发明的嘧啶和吡啶衍生物可用于治疗,改善或预防响应于间变性淋巴瘤激酶(ALK)活性,粘着斑激酶(FAK),ζ-链相关蛋白激酶70 (ZAP-70),胰岛素样生长因子(IGF-1R)或其组合。
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公开(公告)号:US08372858B2
公开(公告)日:2013-02-12
申请号:US13048636
申请日:2011-03-15
申请人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人: Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号: A61K31/505 , A61K31/535 , A61K31/03 , C07D239/42 , C07D403/12 , C07D239/02
CPC分类号: A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要: The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号:US20120165310A1
公开(公告)日:2012-06-28
申请号:US13394534
申请日:2010-09-10
申请人: Bei Chen , Robin Alec Fairhurst , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Jiang Songchun , Wenshuo Lu , Thomas H. Marsilje, III , Clive McCarthy , Pierre-Yves Michellys , Frederic Stauffer , Stefan Stutz , Andrea Vaupel
发明人: Bei Chen , Robin Alec Fairhurst , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Jiang Songchun , Wenshuo Lu , Thomas H. Marsilje, III , Clive McCarthy , Pierre-Yves Michellys , Frederic Stauffer , Stefan Stutz , Andrea Vaupel
IPC分类号: A61K31/519 , A61K31/541 , C07D493/08 , A61K31/5377 , A61K31/554 , A61P19/00 , A61K31/5386 , C07D495/08 , A61P35/00 , A61P11/00 , A61P1/16 , C07D487/04 , C07D487/08
CPC分类号: C07D487/04 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2059 , A61K9/4858
摘要: The invention relates to compounds of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; such compounds as a medicament; such compounds for the treatment of a proliferative disease.
摘要翻译: 本发明涉及式I化合物,其中取代基如说明书中所定义; 制备这些化合物的方法; 包含这些化合物的药物组合物; 诸如药物的化合物; 这种化合物用于治疗增殖性疾病。
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公开(公告)号:US09440957B2
公开(公告)日:2016-09-13
申请号:US14405773
申请日:2013-06-05
申请人: Gerald Lelais , Robert Epple , Thomas H. Marsilje, III , Pierre-Yves Michellys , Matthew McNeill , Yun Long , Wenshuo Lu , Bei Chen , Badry Bursulaya , Songchun Jiang
发明人: Gerald Lelais , Robert Epple , Thomas H. Marsilje, III , Pierre-Yves Michellys , Matthew McNeill , Yun Long , Wenshuo Lu , Bei Chen , Badry Bursulaya , Songchun Jiang
IPC分类号: A61K31/55 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D411/14 , C07D413/14 , C07D417/14 , A61K31/4184 , A61K31/454 , A61K31/4545 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D413/04 , C07D471/04 , C07D513/04
CPC分类号: C07D401/14 , A61K31/4184 , A61K31/454 , A61K31/4545 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要: The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated EGFR activity.
摘要翻译: 本发明提供了可用于调节EGFR活性的化合物及其药物组合物,以及使用这些化合物治疗,改善或预防与异常或失调的EGFR活性相关的病症的方法。
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