摘要:
An implantable phototherapy device includes a power receiver element configured to receive power from an external power transmitter, a light delivery element powered by the power receiver, and configured to deliver phototherapy to a target treatment area, and a tether element is coupled to the light delivery element and the power receiver element. The tether element is configured to deliver power between the power receiver element and the light delivery element.
摘要:
A first quality of service identifier is assigned to each subtask associated with each node of a compute workflow, the first quality of service identifier indicative of a level of quality of service associated with each node. A planned resource requirement is assigned to each subtask, the planned resource requirement indicative of a total amount of system resources required to complete each subtask. A resource allocation plan is generated for each subtask, the resource allocation plan indicative of a distribution of the system resources over time in at least one resource manager. The resource allocation plan and the first quality of service identifier are output to the at least one resource manager for enforcement of the level of quality of service on one or more jobs submitted for each node through at least one workflow orchestrator external to the at least one resource manager.
摘要:
The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-1R), and/or insulin receptor (InsR) or a combination thereof.
摘要:
The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要:
Described herein are compounds that have a spiro structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent diseases or conditions associated with the activity of steroid hormone nuclear receptors.
摘要:
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorder associated with the activation of steroid hormone nuclear receptors.
摘要:
The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要:
The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要:
The invention relates to triazine and pyrimidine derivatives having Formula (1) or (2), and methods for using such compounds. For example, the compounds of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-IR), and/or insulin receptor (InsR) or a combination thereof.
摘要:
A rear-wheel skating shoe provides an enhanced shoe stand with a single fulcrum for a wheel axle to make the structure at positions between a sidewall and a wheel axle and between a sidewall and a bottom plate of the shoe stand stronger to facilitate exposing luminous wheels and protect a user's safety effectively. The shoe includes a left shoe stand, a right shoe stand, a metal screw rod at external sidewalls of the shoe stands, a luminous wheel on the metal screw rod, a left reinforced stand in a sidewall of the left shoe stand, a right reinforced stand in a sidewall of the right shoe stand, and a reinforced plate at the bottom of the bottom plate of the shoe stand and connected to the right reinforced stand. The metal reinforced elements of the skating shoe give a strong structure, and the luminous wheels provide a color effect.