发明申请
- 专利标题： COMBINATION THERAPY FOR THE TREATMENT OF CANCER AND IMMUNOSUPPRESSION
- 专利标题（中）： 用于治疗癌症和免疫抑制的组合治疗
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申请号： US14413122申请日： 2013-07-03
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公开(公告)号： US20150157622A1公开(公告)日： 2015-06-11
- 发明人: Jens Pohlmann , Don Gary Benjamin , Christoph Moroni
- 申请人： Basilea Pharmaceutica AG , Universität Basel
- 优先权： EP12175724.9 20120710
- 国际申请： PCT/EP2013/064048 WO 20130703
- 主分类号： A61K31/475
- IPC分类号： A61K31/475 ; G01N33/50 ; A61K45/06 ; A61K31/365 ; C07D471/14 ; A61K31/155
摘要：
The invention relates to novel Rauwolfia alkaloid derivatives of formula (I) combinations of Rauwolfia alkaloid derivatives and a mitochondrial inhibitor, e.g. metformin, and the use of Rauwolfia alkaloid derivatives in combination with mitochondrial inhibitor for the treatment of cancer and for achieving clinical immunosuppression. The invention also relates to a fluorescence-based method for predicting the sensitivity of a cancer cell towards a compound of formula (I).
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