公开(公告)号：US20250057951A1

公开(公告)日：2025-02-20

申请号：US18719780

申请日：2022-12-16

Applicant: UNIVERSITÄT BASEL ,  CIMEIO THERAPEUTICS AG

Inventor： Stefanie URLINGER ,  Rosalba LEPORE ,  Lukas JEKER ,  Amélie WIEDERKEHR ,  Alessandro SINOPOLI ,  Anna CAMUS ,  Lisa WELLINGER ,  Romina MATTER-MARONE

IPC: A61K39/00

Abstract: The present disclosure relates to the use of cells having discernible surface protein with engineered or naturally occurring mutation(s) but functional surface protein for use in therapy. The present invention also relates to the use of cells having discernible CD117 surface protein variants but functional surface protein for use in therapy, in particular adoptive cell therapy.

公开(公告)号：US12208145B2

公开(公告)日：2025-01-28

申请号：US18172094

申请日：2023-02-21

Applicant: Universität Basel ,  Paul Scherrer Institute

Inventor： Cristina Müller ,  Roger Schibli ,  Nicholas Philip Van Der Meulen ,  Francesca Borgna ,  Damian Wild ,  Melpomeni Fani

IPC: A61K51/08 ,  A61K9/00 ,  A61K9/08 ,  A61K47/12 ,  A61K47/22 ,  A61K51/12 ,  A61P35/00

Abstract: A radiopeptide is provided which comprises (a) a radionuclide, wherein the radionuclide is terbium-161, (b) a chelator coordinating terbium-161, and (c) a peptide or peptide analogue, which is a somatostatin receptor (SSTR) antagonist. The radiopeptide is suitable for use in the treatment of tumor diseases.

公开(公告)号：US12196740B2

公开(公告)日：2025-01-14

申请号：US18340912

申请日：2023-06-26

Applicant: UNIVERSITÄT BASEL

Inventor： Marija Plodinec ,  Ellen Obermann ,  Philipp Oertle ,  Christian Räz

IPC: G01N3/42 ,  G01N3/00 ,  G01N3/06 ,  G01N33/48 ,  G01N33/483 ,  G01N33/574 ,  G01Q60/24 ,  G01Q60/36

Abstract: The invention relates to a method for classifying a tissue sample obtained from mammary carcinoma. The method comprises determining a stiffness value for each of a plurality of points on said tissue sample, resulting in a stiffness distribution, and assigning said sample to a breast cancer subtype and nodal status based on said stiffness distribution.

公开(公告)号：US20240282424A1

公开(公告)日：2024-08-22

申请号：US18654586

申请日：2024-05-03

Applicant: Universität Basel

Inventor： Gabor Szinnai ,  Gilbert Koch ,  Marc Pfister ,  Johannes Schropp ,  Britta Steffens ,  Freya Bachmann

IPC: G16H20/10 ,  A61B5/024 ,  G06N3/02 ,  G16H50/50

CPC classification number: G16H20/10 ,  A61B5/02438 ,  G06N3/02 ,  G16H50/50

Abstract: The present description relates to a method for automatically determining an optimal individual dosing regimen of at least one drug. The method includes providing a mathematical model adapted to model a progression of said disease and an effect of the at least one drug on the progression of the disease, the model comprising individual model parameters associated with the patient. The method includes utilizing an empirical Bayesian estimation to automatically and numerically estimate the individual model parameters of the mathematical model. The method includes automatically calculating an optimal individual dosing regimen for the mathematical model by solving an optimal control problem based on a desired progression of the disease, the estimated individual model parameters, and an initial guess for the dosing regimen. The method includes adjusting the optimal individual dosing regimen to optionally account for at least one clinical constraint to yield the optimal individual dosing regimen.

公开(公告)号：US20240060812A1

公开(公告)日：2024-02-22

申请号：US18260077

申请日：2021-12-16

Applicant: Endress+Hauser SE+Co. KG ,  Universität Basel

Inventor： Raphael Kuhnen ,  Mohammad Sadegh Ebrahimi ,  Johannes Kölbl

IPC: G01F23/292

CPC classification number: G01F23/2922

Abstract: A sensor device for determining and/or monitoring a process variable of a medium in a container includes: a crystal body having at least one defect; and a magnetic field device for generating a magnetic field, the magnetic field device arranged such that a magnetic field can be generated in the region of the crystal body and in the region of the medium located within the container, so that a change of the magnetic field in the region of the crystal body is amplified, wherein the crystal body and the magnetic field device are arranged from the outside on a wall of the container. A method for determining and/or monitoring a process variable of a medium in a container using the sensor device is also disclosed.

公开(公告)号：US20240059650A1

公开(公告)日：2024-02-22

申请号：US18256992

申请日：2021-12-13

Applicant: DSM IP ASSETS B.V. ,  UNIVERSITÄT BASEL

Inventor： Werner BONRATH ,  Thomas BUCHHOLZ ,  Thomas NETSCHER ,  Jan SCHUETZ ,  Christof SPARR

IPC: C07C407/00

CPC classification number: C07C407/00 ,  C07C2601/16

Abstract: The present invention relates to the photooxidation of 2,4,6-trimethyl-phenol to yield 4-hydroperoxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one using methylene blue as photosensitizer in a solvent mixture of water and alcohols using light of the high wavelength range of the visible spectrum. This process allows 5 obtaining 4-hydroxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one and 2,3,5-trimethyl-hydroquinone in high yields and selectivity from 2,4,6-trimethylphenol.

公开(公告)号：US11904051B2

公开(公告)日：2024-02-20

申请号：US16966626

申请日：2019-01-31

Applicant: Universität Basel ,  Universität Freiburg

Inventor： Bert Müller ,  Andreas Zumbühl ,  Thomas Pfohl ,  Dennis Müller ,  Frederik Neuhaus ,  Radu Tanasescu ,  Till Saxer ,  Marzia Buscema ,  Sofiya Matviykiv ,  Gabriela Gerganova

IPC: A61K9/127 ,  A61K47/24 ,  A61K47/44

CPC classification number: A61K9/127 ,  A61K47/24 ,  A61K47/44

Abstract: A liposome vesicle comprising a membrane consisting of 1,3-diheptadecanamidopropan-2-yl(2-(trimethylammonio)ethyl)phosphate surrounding a volume comprising a pharmaceutical drug or contrast agent. The vesicle is mechanosensitive at body temperature and at physiologically or pathophysiologically relevant shear stress.

公开(公告)号：US20240016370A1

公开(公告)日：2024-01-18

申请号：US18251450

申请日：2021-11-05

Applicant: UNIVERSITÄT BASEL

Inventor： Lorin FASEL ,  Nicolas GERIG ,  Georg RAUTER

IPC: A61B1/005 ,  A61B1/00 ,  A61B1/008 ,  A61B90/00

CPC classification number: A61B1/0052 ,  A61B1/00006 ,  A61B1/0057 ,  A61B1/008 ,  A61B90/06 ,  A61B2090/064

Abstract: An endodevice is disclosed with tension control. The endodevice includes a back end unit with an endoscopic unit coupled thereto. The back end unit includes first and second sensor elements, wherein the first sensor element is arranged between a drive member and a first spring element and the second sensor element is arranged between another end of the first spring element and a first tendon coupler. Each of the first and second sensor elements are configured to generate a sensor signal wherein the first sensor element, the second sensor element and the drive member are connected to a control unit. The control unit is configured to obtain sensor signals from the first sensor element and the second sensor element and to compute a deflection of the first spring element on the basis of the sensor signals obtained from the first sensor element and the second sensor element.

公开(公告)号：US20230344201A1

公开(公告)日：2023-10-26

申请号：US18005605

申请日：2021-07-15

Applicant: UNIVERSITÄT BASEL

Inventor： Richard J. WARBURTON ,  Alisa JAVADI ,  Daniel NAJER ,  Natasha TOMM

IPC: H01S5/34 ,  H01S5/10 ,  H01S5/04 ,  G02B21/06 ,  H01S5/183

CPC classification number: H01S5/3412 ,  H01S5/1042 ,  H01S5/041 ,  G02B21/06 ,  H01S5/18361

Abstract: The present invention relates to a single photon source, comprising: a microcavity arranged between a concave first minor and a semiconductor heterostructure forming a planar second minor, wherein the microcavity supports an optical mode, a quantum dot embedded in the semiconductor heterostructure and facing the first minor, and a laser light source configured to provide laser light in the microcavity to excite the quantum dot to emit single photons exiting the microcavity.

公开(公告)号：US11702459B2

公开(公告)日：2023-07-18

申请号：US16563987

申请日：2019-09-09

Applicant: UNIVERSITÄT BASEL

Inventor： Gennaro De Libero ,  Marco Lepore ,  Lucia Mori

IPC: C07K14/725 ,  C12N5/0783 ,  G01N1/30 ,  G01N33/569 ,  C12N5/09 ,  C12N15/85 ,  A61K35/17 ,  A61P35/00

CPC classification number: C07K14/7051 ,  A61K35/17 ,  A61P35/00 ,  C12N5/0636 ,  C12N5/0693 ,  C12N15/85 ,  G01N1/30 ,  G01N33/56966 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2502/1114 ,  C12N2502/30

Abstract: The invention relates to a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR1 molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells.
The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.