发明申请
US20150166786A1 POLY((LACTIC-CO-GLYCOLIC ACID)-B-LYSINE) AND PROCESS FOR SYNTHESIZING A BLOCK COPOLYMER OF PLGA AND PLL (POLY-E-CBZ-L-LYSINE)
审中-公开
聚（（LACTIC-CO-GLYCOLIC ACID）-B-LYSINE）和合成PLGA和PLL嵌段共聚物（聚-E-CBZ-L-赖氨酸）的方法
- 专利标题： POLY((LACTIC-CO-GLYCOLIC ACID)-B-LYSINE) AND PROCESS FOR SYNTHESIZING A BLOCK COPOLYMER OF PLGA AND PLL (POLY-E-CBZ-L-LYSINE)
- 专利标题（中）： 聚（（LACTIC-CO-GLYCOLIC ACID）-B-LYSINE）和合成PLGA和PLL嵌段共聚物（聚-E-CBZ-L-赖氨酸）的方法
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申请号： US14232525申请日： 2012-07-13
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公开(公告)号： US20150166786A1公开(公告)日： 2015-06-18
- 发明人: John Harvey , Daniel Siegwart , Heng Huang , Brian Hess , Alex Aimetti
- 申请人： John Harvey , Daniel Siegwart , Heng Huang , Brian Hess , Alex Aimetti
- 申请人地址： US MA Cambridge
- 专利权人： InVivo Therapeutics Corp.
- 当前专利权人： InVivo Therapeutics Corp.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US2012/046687 WO 20120713
- 主分类号： C08L67/08
- IPC分类号： C08L67/08 ; A61K47/34
摘要：
A method of synthesizing copolymers is provided. The method can include coupling a degradable polymer to a poly(amino acid) and then deprotecting the copolymer if the poly(amino acid) contains protected side chains. Copolymer compositions are provided. These compositions include PLGA-PLL copolymers, PLGA-PLL-cbz copolymers, and copolymers of a polyester with a carboxylic acid end group coupled to a poly(amino acid) with an amine group. The compositions may include therapeutic blends and formulations of copolymers.
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