发明申请
- 专利标题： Spectral Imaging for Measurement of Nuclear Pathology Features in Cancer Cells Prepared for In Situ Analysis
- 专利标题（中）： 用于测量原位分析的癌细胞中核病理特征的光谱成像
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申请号： US14115327申请日： 2013-04-23
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公开(公告)号： US20150197811A9公开(公告)日： 2015-07-16
- 发明人: Francesca Demichelis , Karl Garsha , Phillip C. Miller , Ray B. Nagle , Michael Otter , Gary Anthony Pestano , Mark Rubin
- 申请人： Francesca Demichelis , Karl Garsha , Phillip C. Miller , Ray B. Nagle , Michael Otter , Gary Anthony Pestano , Mark Rubin
- 申请人地址： US NY Ithaca US AZ Tucson
- 专利权人： CORNELL UNIVERSITY,VENTANA MEDICAL SYSTEMS, INC.
- 当前专利权人： CORNELL UNIVERSITY,VENTANA MEDICAL SYSTEMS, INC.
- 当前专利权人地址： US NY Ithaca US AZ Tucson
- 优先权： DE102012208470.3 20120521
- 国际申请： PCT/EP13/58356 WO 20130423
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G06F19/18
摘要：
In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
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