公开(公告)号：US08788049B2

公开(公告)日：2014-07-22

申请号：US12299043

申请日：2007-05-01

Applicant: Eyal Lasko ,  Shmuel Springer ,  Mark Rubin ,  Amit Dar

Inventor： Eyal Lasko ,  Shmuel Springer ,  Mark Rubin ,  Amit Dar

IPC: A61N1/00

CPC classification number: A61N1/36003 ,  A61B5/1038 ,  A61H3/00 ,  A61N1/0452 ,  A61N1/0484 ,  A61N1/36014 ,  G01L1/20 ,  H01H3/14 ,  H03K17/9625

Abstract: A gait modulation system including: (a) a sensor device including a sensor adapted for associating with at least one lower limb of the patient, the sensor for transducing at least one parameter related to a gait of the patient, so as to obtain gait data related to the gait, and (b) a muscle stimulator including: (i) an electrical stimulation circuit, the circuit adapted to supply an electrical stimulation output to an electrode array for performing functional electrical stimulation of at least one muscle of the lower limb, and (ii) a microprocessor, operatively connected to the at least one sensor, the microprocessor adapted for: receiving a stream of gait information based on the gait data; processing the gait information, and controlling the stimulation output based on the processing of the gait information, and wherein the microprocessor is further adapted to identify a failure in the stream of gait information, and to consequently control the electrical stimulation circuit to deliver a fail-safe stimulation output over a portion of a duration of the failure.

Abstract translation: 一种步态调制系统，包括：（a）传感器装置，其包括适于与患者的至少一个下肢相关联的传感器，所述传感器用于转导与患者的步态相关的至少一个参数，以便获得步态数据 和（b）肌肉刺激器，其包括：（i）电刺激电路，所述电路适于向电极阵列提供电刺激输出，用于对下肢的至少一个肌肉进行功能性电刺激， 以及（ii）可操作地连接到所述至少一个传感器的微处理器，所述微处理器适于：基于所述步态数据接收步态信息流; 处理步态信息，以及基于步态信息的处理来控制刺激输出，并且其中所述微处理器还适于识别所述步态信息流中的故障，并且因此控制所述电刺激电路以递送故障信息， 在故障持续时间的一部分时间内产生安全刺激输出。

公开(公告)号：US20140037561A1

公开(公告)日：2014-02-06

申请号：US13983464

申请日：2011-02-03

Applicant: John E. Kulesza ,  Mark Rubin

Inventor： John E. Kulesza ,  Mark Rubin

IPC: A61K8/36 ,  A61K8/49 ,  A61Q19/08 ,  A61K8/34

CPC classification number: A61K8/36 ,  A61K8/345 ,  A61K8/347 ,  A61K8/4953 ,  A61K31/07 ,  A61K31/19 ,  A61K31/355 ,  A61K31/60 ,  A61K45/06 ,  A61Q19/08 ,  A61K2300/00

Abstract: A composition is provided that capitalizes on the biological activity of trichloroacetic acid, but effectively reduces or eliminates TCA induced irritation allowing the composition to be used as a wrinkle effacer or stimulant of skin cell turnover; uses previously thought as commercially impossible with TCA. Also provided are processes of effacing wrinkles or stimulating skin cell turnover including applying the inventive composition to the skin of a subject.

Abstract translation: 提供了一种利用三氯乙酸的生物活性的组合物，但有效地减少或消除了TCA诱导的刺激，使组合物可用作皮肤细胞周转的皱纹或刺激物; 以前被认为是商业上不可能用于TCA的用途。 还提供了消除皱纹或刺激皮肤细胞周转的过程，包括将本发明组合物应用于受试者的皮肤。

公开(公告)号：US08080839B2

公开(公告)日：2011-12-20

申请号：US12549906

申请日：2009-08-28

Applicant: Sandip Tiwari ,  Moon-Kyung Kim ,  Joshua Mark Rubin ,  Soo-Doo Chae ,  Choong-Man Lee ,  Ravishankar Sundararaman

Inventor： Sandip Tiwari ,  Moon-Kyung Kim ,  Joshua Mark Rubin ,  Soo-Doo Chae ,  Choong-Man Lee ,  Ravishankar Sundararaman

IPC: H01L29/84

CPC classification number: H01L49/00 ,  B82Y10/00 ,  G11C13/025 ,  G11C23/00

Abstract: An electro-mechanical transistor includes a source electrode and a drain electrode spaced apart from each other. A source pillar is between the substrate and the source electrode. A drain pillar is between the substrate and the drain electrode. A moveable channel is spaced apart from the source electrode and the drain electrode. A gate nano-pillar is between the moveable channel and the substrate. A first dielectric layer is between the moveable channel and the gate nano-pillar. A second dielectric layer is between the source pillar and the source electrode. A third dielectric layer is between the drain pillar and the drain electrode.

Abstract translation: 机电晶体管包括彼此间隔开的源电极和漏电极。 源极柱位于衬底和源电极之间。 漏极柱位于衬底和漏电极之间。 可移动通道与源电极和漏电极间隔开。 门纳米柱位于可移动通道和基板之间。 第一电介质层位于可移动沟道和栅极纳米柱之间。 第二电介质层位于源极柱和源极之间。 第三介电层位于漏极柱和漏极之间。

公开(公告)号：US20080008704A1

公开(公告)日：2008-01-10

申请号：US11732204

申请日：2007-04-02

Applicant: Mark Rubin

Inventor： Mark Rubin

IPC: A61K39/395 ,  A61P35/00

CPC classification number: C07K16/2863 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  A61K2300/00

Abstract: A method for treating colorectal cancer is disclosed and consists of administering to a patient in need of such treatment a pharmaceutically effective dose of an agent capable of blocking the binding of EGF-receptor to its natural ligand(s) and/or inhibiting EGF-receptor-mediated signaling. Also disclosed is a method of increasing a colorectal cancer patient response to anti-cancer therapy which consists of administering to said patient a pharmaceutically effective dose of an agent capable of blocking the binding of EGF-receptor to its natural ligand(s) and/or inhibiting EGF-receptor-mediated signaling.

Abstract translation: 公开了一种治疗结肠直肠癌的方法，其包括向需要这种治疗的患者施用药物有效剂量的能够阻断EGF受体与其天然配体结合和/或抑制EGF-受体的药剂 介导的信号。 还公开了增加结肠直肠癌患者对抗癌疗法的反应的方法，其包括向所述患者施用药学有效剂量的能够阻断EGF受体与其天然配体和/或 抑制EGF受体介导的信号传导。

公开(公告)号：US20060234259A1

公开(公告)日：2006-10-19

申请号：US11361517

申请日：2006-02-24

Applicant: Mark Rubin ,  Francesca Demichelis

Inventor： Mark Rubin ,  Francesca Demichelis

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2500/10

Abstract: The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose expression, at the transcriptional and protein levels, is correlated with prostate cancer progression. Methods and kits are described for using these gene expression profiles in the study and/or diagnosis of prostate cancer diseases, in the prediction of prostate cancer progression, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that target these genes or their protein products, in particular for the development of therapeutics for modulating prostate cancer progression.

Abstract translation: 本发明涉及与前列腺癌临床相关的基因表达谱的鉴定和使用。 特别地，本发明提供了在转录和蛋白质水平上表达与前列腺癌进展相关的基因的身份。 描述了在前列腺癌疾病的研究和/或诊断，前列腺癌进展的预测以及治疗方案的选择和/或监测中使用这些基因表达谱的方法和试剂盒。 本发明还涉及靶向这些基因或其蛋白质产物的药物的筛选，特别是用于开发用于调节前列腺癌进展的治疗剂。

公开(公告)号：US20050108118A1

公开(公告)日：2005-05-19

申请号：US10718041

申请日：2003-11-18

Applicant: James Malackowski ,  Andrew Carter ,  Mark Rubin

Inventor： James Malackowski ,  Andrew Carter ,  Mark Rubin

IPC: G06Q99/00 ,  G06F17/60

CPC classification number: G06Q99/00 ,  G06Q40/12

Abstract: A method of utilizing an intellectual property grouping owned by a patent entity to generate income. The method includes acquiring rights in a first intellectual property asset from a seller on behalf of a patent investment entity, providing compensation to the seller in exchange for the first intellectual property asset, granting less than all of the rights in the first intellectual property asset to the seller of the intellectual property asset in exchange for a stream of payments, wherein granting less than all of the rights in the first intellectual property asset creates residual rights in the first intellectual property asset, and utilizing the residual rights in the first intellectual property asset to generate income for the patent investment entity.

Abstract translation: 利用专利实体拥有的知识产权分类产生收入的方法。 该方法包括代表专利投资实体从卖方获得第一知识产权资产的权利，为卖方交换第一知识产权资产提供赔偿，给予第一知识产权资产的全部权利少于 知识产权资产的卖方换取一笔付款，其中授予的第一知识产权资产的所有权利少于第一知识产权资产的剩余权利，并利用第一知识产权资产的剩余权利 为专利投资实体创造收入。

公开(公告)号：US06211045B1

公开(公告)日：2001-04-03

申请号：US09452291

申请日：1999-11-30

Applicant: Victor Liang ,  Mark Rubin ,  Bijan Moslehi

Inventor： Victor Liang ,  Mark Rubin ,  Bijan Moslehi

IPC: H01L214763

CPC classification number: H01L21/28247 ,  H01L21/3144

Abstract: A method is presented in which nitrogen-based gas in incorporated in polysilicon gate re-oxidation to improve hot carrier performance. A gate oxide layer is formed. Gate material is deposited on the gate oxide layer. The gate material is etched to form a gate structure. The gate oxide layer and the gate are re-oxidized. During re-oxidation, nitrogen-based gas is introduced to nitridize re-oxidized portions of the gate oxide layer.

Abstract translation: 提出了一种纳入多晶硅栅极再氧化中的氮基气体以改善热载体性能的方法。 形成栅氧化层。 栅极材料沉积在栅极氧化物层上。 栅极材料被蚀刻以形成栅极结构。 栅极氧化层和栅极被再次氧化。 在再氧化过程中，引入氮基气体以氮化栅极氧化物层的再氧化部分。

公开(公告)号：US20110049650A1

公开(公告)日：2011-03-03

申请号：US12549906

申请日：2009-08-28

Applicant: Sandip Tiwari ,  Moon-Kyung Kim ,  Joshua Mark Rubin ,  Soo-Doo Chae ,  Choong-Man Lee ,  Ravishankar Sundararaman

Inventor： Sandip Tiwari ,  Moon-Kyung Kim ,  Joshua Mark Rubin ,  Soo-Doo Chae ,  Choong-Man Lee ,  Ravishankar Sundararaman

IPC: H01L29/84

CPC classification number: H01L49/00 ,  B82Y10/00 ,  G11C13/025 ,  G11C23/00

Abstract: An electromechanical transistor includes a source electrode and a drain electrode spaced apart from each other. A source pillar is between the substrate and the source electrode. A drain pillar is between the substrate and the drain electrode. A moveable channel is spaced apart from the source electrode and the drain electrode. A gate nano-pillar is between the moveable channel and the substrate. A first dielectric layer is between the moveable channel and the gate nano-pillar. A second dielectric layer is between the source pillar and the source electrode. A third dielectric layer is between the drain pillar and the drain electrode.

Abstract translation: 机电晶体管包括彼此间隔开的源电极和漏电极。 源极柱位于衬底和源电极之间。 漏极柱位于衬底和漏电极之间。 可移动通道与源电极和漏电极间隔开。 门纳米柱位于可移动通道和基板之间。 第一电介质层位于可移动沟道和栅极纳米柱之间。 第二电介质层位于源极柱和源极之间。 第三介电层位于漏极柱和漏极之间。

公开(公告)号：US20090210273A1

公开(公告)日：2009-08-20

申请号：US12322227

申请日：2009-01-30

Applicant: Mark Rubin

Inventor： Mark Rubin

IPC: G06Q10/00

CPC classification number: G06Q10/06 ,  G06Q10/04 ,  G06Q10/06393 ,  G06Q40/00

Abstract: Systems and methods for providing visualizing business functions and/or operations using at least one visual representation of the energy and information systems, in addition to human resource elements, for representing a business and its operating efficiency.

Abstract translation: 使用能量和信息系统的至少一个视觉表示来提供可视化业务功能和/或操作的系统和方法，以及用于表示业务及其操作效率的人力资源元素。

公开(公告)号：US20090083688A1

公开(公告)日：2009-03-26

申请号：US11860775

申请日：2007-09-25

Applicant: Victor Moroz ,  Xi-Wei Lin ,  Mark Rubin

Inventor： Victor Moroz ,  Xi-Wei Lin ,  Mark Rubin

IPC: G06F17/50

CPC classification number: G06F17/5068

Abstract: A system that generates a layout for a transistor is presented. During operation, the system receives a transistor library which includes operating characteristics of fabricated transistors correlated to transistor gate shapes. The system also receives one or more desired operating characteristics for the transistor. Next, the system determines a transistor gate shape for the transistor based on the transistor library so that a fabricated transistor with the transistor gate shape substantially achieves the one or more desired operating characteristics. The system then generates the layout for the transistor which includes the transistor gate shape.

Abstract translation: 提出了一种产生晶体管布局的系统。 在操作期间，系统接收晶体管库，其包括与晶体管栅极形状相关的制造晶体管的工作特性。 该系统还接收晶体管的一个或多个期望的工作特性。 接下来，系统基于晶体管库确定用于晶体管的晶体管栅极形状，使得具有晶体管栅极形状的制造晶体管基本上实现一个或多个期望的工作特性。 然后，系统产生包括晶体管栅极形状的晶体管的布局。