发明申请
US20150238662A1 SUSTAINED NITRIC OXIDE RELEASE COATING USING DIAZENIUMDIOLATE-DOPED POLYMER MATRIX WITH ESTER CAPPED POLY(LACTIC-CO-GLYCOLIC ACID) ADDITIVE
有权
使用具有ESTER CAPPED POLY（LACTIC-CO-GLYCOLIC ACID）添加剂的DIAZENIUMPOLATE-DOPED POLYMER MATRIX的持久氮氧化物涂层
- 专利标题： SUSTAINED NITRIC OXIDE RELEASE COATING USING DIAZENIUMDIOLATE-DOPED POLYMER MATRIX WITH ESTER CAPPED POLY(LACTIC-CO-GLYCOLIC ACID) ADDITIVE
- 专利标题（中）： 使用具有ESTER CAPPED POLY（LACTIC-CO-GLYCOLIC ACID）添加剂的DIAZENIUMPOLATE-DOPED POLYMER MATRIX的持久氮氧化物涂层
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申请号： US14430545申请日： 2013-09-25
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公开(公告)号： US20150238662A1公开(公告)日： 2015-08-27
- 发明人: Hitesh Handa , Mark E. Meyerhoff , Robert H. Bartlett , Elizabeth J. Brisbois , Lahdan Refahiyat
- 申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 国际申请： PCT/US13/61665 WO 20130925
- 主分类号： A61L31/16
- IPC分类号： A61L31/16 ; A61L29/14 ; A61L29/04 ; A61L29/16 ; A61L31/04 ; A61L31/14
摘要：
A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.
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