公开(公告)号：US09566372B2

公开(公告)日：2017-02-14

申请号：US14430545

申请日：2013-09-25

申请人： The Regents of the University of Michigan

发明人： Hitesh Handa ,  Mark E. Meyerhoff ,  Robert H. Bartlett ,  Elizabeth J. Brisbois ,  Lahdan Refahiyat

IPC分类号： A61L31/16 ,  C08L27/06 ,  C08G18/61 ,  A61L29/04 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61L31/14

CPC分类号： A61L31/16 ,  A61L29/049 ,  A61L29/141 ,  A61L29/16 ,  A61L31/041 ,  A61L31/141 ,  A61L2300/114 ,  A61L2300/802 ,  C08G18/61 ,  C08K5/32 ,  C08L27/06 ,  C08L67/04 ,  C08L83/04

摘要： A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.

摘要翻译： 聚合物组合物包括具有亲脂性离散一氧化氮加合物和/或与其相关的聚合一氧化氮加合物的聚合物基质，通过共价连接到聚合物基质和/或通过聚合物基质内的分散体与离散的一氧化氮加合物和/ 或能够释放一氧化氮（NO）的聚合一氧化氮加合物。 所述聚合物组合物还包含酯封端的聚（丙交酯 - 共 - 乙交酯）（PLGA）添加剂，用于增加，延长和控制来自亲脂性离散一氧化氮加合物和/或聚合一氧化氮加合物的NO释放速率中的至少一种。

公开(公告)号：US20150238662A1

公开(公告)日：2015-08-27

申请号：US14430545

申请日：2013-09-25

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Hitesh Handa ,  Mark E. Meyerhoff ,  Robert H. Bartlett ,  Elizabeth J. Brisbois ,  Lahdan Refahiyat

IPC分类号： A61L31/16 ,  A61L29/14 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/14

CPC分类号： A61L31/16 ,  A61L29/049 ,  A61L29/141 ,  A61L29/16 ,  A61L31/041 ,  A61L31/141 ,  A61L2300/114 ,  A61L2300/802 ,  C08G18/61 ,  C08K5/32 ,  C08L27/06 ,  C08L67/04 ,  C08L83/04

摘要： A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.

摘要翻译： 聚合物组合物包括具有亲脂性离散一氧化氮加合物和/或与其相关的聚合一氧化氮加合物的聚合物基质，通过共价连接到聚合物基质和/或通过聚合物基质内的分散体与离散的一氧化氮加合物和/ 或能够释放一氧化氮（NO）的聚合一氧化氮加合物。 所述聚合物组合物还包含酯封端的聚（丙交酯 - 共 - 乙交酯）（PLGA）添加剂，用于增加，延长和控制来自亲脂性离散一氧化氮加合物和/或聚合一氧化氮加合物的NO释放速率中的至少一种。

公开(公告)号：US10589015B2

公开(公告)日：2020-03-17

申请号：US15519760

申请日：2015-10-19

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Robert H. Bartlett ,  Joseph L. Bull ,  Uditha Piyumindri Fernando

IPC分类号： A61M1/16 ,  B01D63/02

摘要： An artificial lung including a housing having a circular outer wall being enclosed by a first surface and a second surface to define an interior volume, a blood inlet port to permit inlet flow of blood to the housing, a blood outlet port to permit outlet flow of the blood from the housing, a gas inlet port to permit inlet flow of a gas to the housing, a gas outlet port to permit outlet flow of the gas from the housing, and a plurality of baffles concentrically disposed within the housing. The baffles are positioned to define a flow path between the blood inlet port and the blood outlet port. Each of the baffles includes a gate opening to permit flow of the blood along the flow path. A fiber bundle is disposed between the baffles within the flow create mixing and improve gas exchange efficiency.

公开(公告)号：US20170216550A1

公开(公告)日：2017-08-03

申请号：US15484981

申请日：2017-04-11

申请人： The Regents of the University of Michigan

发明人： Mark E. Meyerhoff ,  Robert H. Bartlett ,  Nicolai Lehnert ,  Yu Qin ,  Andrew P. Hunt ,  Elizabeth J. Brisbois ,  Hang Ren

IPC分类号： A61M16/12 ,  A61M1/34 ,  A61M16/10 ,  A61M1/16 ,  A61M16/08

CPC分类号： A61M16/12 ,  A61M1/1698 ,  A61M1/342 ,  A61M1/3462 ,  A61M16/0875 ,  A61M25/0043 ,  A61M35/00 ,  A61M2016/1025 ,  A61M2016/1035 ,  A61M2025/0057 ,  A61M2202/0208 ,  A61M2202/0275 ,  A61M2202/0007

摘要： A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.