发明申请
- 专利标题： CYCLIC PEPTIDES AND USE AS MEDICINES
- 专利标题（中）： 循环肽和用作药物
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申请号： US14717872申请日： 2015-05-20
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公开(公告)号： US20150306172A1公开(公告)日： 2015-10-29
- 发明人: Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
- 申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 主分类号： A61K38/13
- IPC分类号： A61K38/13 ; A61K45/06 ; C07K7/64
摘要：
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
公开/授权文献
- US09566312B2 Cyclic peptides and use as medicines 公开/授权日：2017-02-14