CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES

Invention Application

US20150328330A1 CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES 有权

Title translation: 聚合物，二磷酸盐和抗血管生成剂的联合及其在骨相关疾病的治疗和监测中的应用

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Patent Title: CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES
Patent Title (中): 聚合物，二磷酸盐和抗血管生成剂的联合及其在骨相关疾病的治疗和监测中的应用
Application No.: US14816228

Application Date: 2015-08-03
Publication No.: US20150328330A1

Publication Date: 2015-11-19
Inventor: Ronit SATCHI-FAINARO , Keren MILLER , Doron SHABAT , Rotem EREZ
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Applicant Address: IL Tel-Aviv
Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Current Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Current Assignee Address: IL Tel-Aviv
Main IPC: A61K47/48
IPC: A61K47/48 ; A61K49/00 ; A61K31/337

CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES

Abstract:

Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.

Abstract(Chinese):

公开了与其连接有抗血管生成剂和双膦酸盐骨靶向剂的聚合物或共聚物的缀合物及其制备方法。还公开了含有这些缀合物的药物组合物及其在治疗骨相关疾病中的用途。

Public/Granted literature

US09427474B2 Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases Public/Granted day:2016-08-30

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