公开(公告)号：US20230303712A1

公开(公告)日：2023-09-28

申请号：US18122194

申请日：2023-03-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Eilam YEINI

IPC: C07K16/28 ,  A61K31/554 ,  C12N15/113 ,  A61P35/00 ,  A61P25/00 ,  A61K45/06

CPC classification number: C07K16/2896 ,  A61K31/554 ,  A61K45/06 ,  A61P25/00 ,  A61P35/00 ,  C12N15/1138 ,  C07K2317/76 ,  C12N2310/531

Abstract: A method of treating glioblastoma in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that specifically decreases an amount and/or activity of P-selectin.

公开(公告)号：US20160229840A1

公开(公告)日：2016-08-11

申请号：US15131129

申请日：2016-04-18

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Doron SHABAT ,  Ronit SATCHI-FAINARO

IPC: C07D401/14 ,  C07D213/30 ,  C07D213/85 ,  G01N33/52 ,  C07D213/71 ,  C07D209/12 ,  A61K49/00 ,  C07D209/08 ,  C07D213/76

CPC classification number: C07D401/14 ,  A61K47/558 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  C07D209/08 ,  C07D209/12 ,  C07D213/30 ,  C07D213/71 ,  C07D213/76 ,  C07D213/85 ,  C09B23/0066 ,  C09B23/086 ,  C09B23/12 ,  G01N33/52 ,  G01N33/582

Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.

Abstract translation: 新的荧光化合物被设计成使得在化学事件上产生能够发射NIR光的化合物被产生。 这些化合物包含两个或多个含受体的部分和可裂解供体的部分，其完全是π-电子共轭并且使得不能使π-电子的离域化。 还公开了在使荧光化合物经历化学事件（例如去质子化）时产生的荧光化合物。 还公开了荧光化合物作为NIR探测的用于监测各种分析物的存在和/或水平的Turn-ON机制的用途。

公开(公告)号：US20230277677A1

公开(公告)日：2023-09-07

申请号：US18140681

申请日：2023-04-28

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Evgeni PISAREVSKY ,  Anat ELDAR-BOOCK ,  Dikla BEN-SHUSHAN ,  Yana EPSHTEIN ,  Anna SCOMPARIN

IPC: A61K47/65 ,  A61K9/51 ,  A61K47/64 ,  A61P35/00 ,  A61K47/59 ,  A61P35/04 ,  A61K31/4184 ,  A61K31/506

CPC classification number: A61K47/65 ,  A61K9/5153 ,  A61K47/645 ,  A61P35/00 ,  A61K47/59 ,  A61P35/04 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/4745

Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.

公开(公告)号：US20200237932A1

公开(公告)日：2020-07-30

申请号：US16850333

申请日：2020-04-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Doron SHABAT ,  Ronit SATCHI-FAINARO ,  Nir HANANYA ,  Ori GREEN ,  Tal EILON

IPC: A61K49/00 ,  C07H15/26 ,  C07F9/12 ,  C09B11/24 ,  C07D321/00 ,  C07F7/18 ,  C09B23/01 ,  C09B23/04 ,  C07F5/02 ,  C07F5/04 ,  C09B23/08 ,  C07F9/655 ,  C09K11/06 ,  C07H15/203

Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.

公开(公告)号：US20150320786A1

公开(公告)日：2015-11-12

申请号：US14803155

申请日：2015-07-20

Applicant: Ramot at Tel-Aviv University Ltd. ,  Freie Universitaet Berlin

Inventor： Rainer HAAG ,  Wiebke FISCHER ,  Abdul Mohiuddin QUADIR ,  Ronit SATCHI-FAINARO ,  Paula OFEK

IPC: A61K31/713 ,  C07C229/22 ,  A61K45/06 ,  C12N15/113 ,  C07C271/20

CPC classification number: A61K31/713 ,  A61K45/06 ,  C07C217/28 ,  C07C229/22 ,  C07C271/20 ,  C12N15/1135

Abstract: The invention relates to a compound suited as entity carrier, having the general formula (I) wherein X is an amine-containing residue further defined herein. The invention further relates to the use of such compounds, a nanocarrier system, a kit comprising such compounds and methods for gene silencing and anti-cancer treatment.

Abstract translation: 本发明涉及一种适合作为实体载体的化合物，具有通式（I），其中X为本文进一步定义的含胺残基。 本发明还涉及这样的化合物，纳米载体系统，包含这些化合物的试剂盒和用于基因沉默和抗癌治疗的方法的用途。

公开(公告)号：US20250019445A1

公开(公告)日：2025-01-16

申请号：US18885825

申请日：2024-09-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Eilam YEINI

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: A method of treating brain-metastasized cancer in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that specifically decreases an amount and/or activity of P-selectin and an immunomodulatory agent. Methods of treating additional cancers are also disclosed.

公开(公告)号：US20180318428A1

公开(公告)日：2018-11-08

申请号：US15764429

申请日：2016-09-30

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Ronit SATCHI-FAINARO ,  Anna SCOMPARIN ,  Dina POLYAK ,  Adva KRIVITSKY ,  Shay ELIYAHU ,  Hadas GIBORI

IPC: A61K47/59 ,  A61K31/7105 ,  A61K31/711 ,  C12N15/113

CPC classification number: C08G69/48 ,  A61K31/7088 ,  A61K38/00 ,  C08G69/10 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2320/32 ,  C12Y207/11001

Abstract: Polymers useful for associating therewith oligonucleotides and for delivering the oligonucleotides into a cell, conjugates comprising these polymers and an oligonucleotide associated therewith, and compositions comprising same are provided. Also provided are uses of these conjugates in, for example, gene therapy, and particularly gene silencing. The disclosed polymers feature a PGA backbone, and amine-terminated pendant groups attached to at least 40% of the backbone units, and optionally further comprise alkyl pendant groups and/or other nitrogen-containing pendant groups attached to other one or more portions of the backbone units. The disclosed polymers can be cross-linked or can form a part of a block-copolymer.

公开(公告)号：US20140079638A1

公开(公告)日：2014-03-20

申请号：US14082224

申请日：2013-11-18

Applicant: Fundacion de la Comunidad Valenciana Centro de Investigacion Principle Felipe ,  Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Maria Jesus Vicent Docon

IPC: A61K47/48 ,  A61K49/00

CPC classification number: A61K47/48315 ,  A61K31/336 ,  A61K31/337 ,  A61K47/50 ,  A61K47/62 ,  A61K47/65 ,  G01N33/6893 ,  G01N2800/042 ,  G01N2800/102 ,  G01N2800/321 ,  G01N2800/323

Abstract: Conjugates of a polymer having attached thereto an angiogenesis targeting moiety and a therapeutically active agent such as an anti-cancer agent or anti-angiogenesis agent, and processes of preparing same are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of angiogenesis-related medical conditions such as cancer and cancer metastases are also disclosed.

Abstract translation: 公开了具有附着于血管生成靶向部分的聚合物和治疗活性剂如抗癌剂或抗血管生成剂的缀合物及其制备方法。 还公开了含有这些缀合物的药物组合物及其在治疗血管发生相关医学病症如癌症和癌症转移中的用途。

公开(公告)号：US20240181070A1

公开(公告)日：2024-06-06

申请号：US18285394

申请日：2022-04-07

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Helena FLORINDO

IPC: A61K47/64 ,  A61K39/00 ,  A61K39/215 ,  A61K47/69

CPC classification number: A61K47/646 ,  A61K39/215 ,  A61K47/6455 ,  A61K47/6937 ,  A61K2039/6093

Abstract: A polymeric nanoparticle is disclosed which comprises: (i) at least one SARS-CoV-2 derived antigen which is capable of producing a T-cell and/or B cell response: and (ii) an antigen presenting cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating COVID-19 is also disclosed.

公开(公告)号：US20240167001A1

公开(公告)日：2024-05-23

申请号：US18424988

申请日：2024-01-29

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit SATCHI-FAINARO ,  Lena NEUFELD

IPC: C12N5/071

CPC classification number: C12N5/0697 ,  C12N2503/02 ,  C12N2513/00

Abstract: A three dimensional (3D) model of a glioblastoma tumor made of a synthetic material and a plurality of cell types, including malignant cells and non-malignant cells of the tumor. Methods of forming the 3D tumor model are also provided, as well as systems in which the 3D tumor model can be perfused and fluidly connected to a medium containing immune cells and/or other cells and factors present in the tumor's microenvironment. Methods utilizing the 3D tumor model or the system in, for example, personalized therapy, are also provided.