Invention Application
- Patent Title: NOTCH-BASED FUSION PROTEINS AND USES THEREOF
- Patent Title (中): 基于NOTCH的融合蛋白及其用途
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Application No.: US14668525Application Date: 2015-03-25
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Publication No.: US20150329615A1Publication Date: 2015-11-19
- Inventor: Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
- Applicant: Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Main IPC: C07K14/705
- IPC: C07K14/705
Abstract:
This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
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