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公开(公告)号：US20100273990A1
公开(公告)日：2010-10-28
申请号：US12657573
申请日：2010-01-21
Applicant: Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
Inventor： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
IPC: C07K16/46
CPC classification number: A61K48/00 , A61K9/0019 , A61K38/00 , C07K14/705 , C07K2319/30 , C07K2319/32
Abstract: This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
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公开(公告)号：US07662919B2
公开(公告)日：2010-02-16
申请号：US11114962
申请日：2005-04-26
Applicant: Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
Inventor： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
CPC classification number: A61K48/00 , A61K9/0019 , A61K38/00 , C07K14/705 , C07K2319/30 , C07K2319/32
Abstract: This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
Abstract translation: 本发明提供了治疗患有肿瘤的受试者的方法和用于抑制受试者血管生成的方法，所述方法包括向受试者施用有效量的包含Notch受体蛋白的细胞外结构域的物质组合物， 生命增加部分。 本发明还提供了包含Notch4受体蛋白的细胞外结构域的物质组合物，其可操作地附着于半衰期增加的部分。 本发明还提供了一种制造品。 最后，本发明提供了可复制载体，其编码包含可操作地附着于半衰期增加部分的Notch受体蛋白的细胞外结构域的多肽，包含该可复制载体的宿主载体系统和产生该多肽的方法。
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公开(公告)号：US20060030694A1
公开(公告)日：2006-02-09
申请号：US11114962
申请日：2005-04-26
Applicant: Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
Inventor： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
IPC: C07K14/705 , C07K16/46 , A61K38/17
CPC classification number: A61K48/00 , A61K9/0019 , A61K38/00 , C07K14/705 , C07K2319/30 , C07K2319/32
Abstract: This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
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公开(公告)号：US08993725B2
公开(公告)日：2015-03-31
申请号：US12657573
申请日：2010-01-21
Applicant: Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
Inventor： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
IPC: A61K38/00 , C07K14/00 , A61K48/00 , C07K14/705 , A61K9/00
CPC classification number: A61K48/00 , A61K9/0019 , A61K38/00 , C07K14/705 , C07K2319/30 , C07K2319/32
Abstract: This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
Abstract translation: 本发明提供了治疗患有肿瘤的受试者的方法和用于抑制受试者血管生成的方法，所述方法包括向受试者施用有效量的包含Notch受体蛋白的细胞外结构域的物质组合物， 生命增加部分。 本发明还提供了包含Notch4受体蛋白的细胞外结构域的物质组合物，其可操作地附着于半衰期增加的部分。 本发明还提供了一种制造品。 最后，本发明提供了可复制载体，其编码包含可操作地附着于半衰期增加部分的Notch受体蛋白的细胞外结构域的多肽，包含该可复制载体的宿主载体系统和产生该多肽的方法。
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公开(公告)号：US20150329615A1
公开(公告)日：2015-11-19
申请号：US14668525
申请日：2015-03-25
Applicant: Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
Inventor： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
IPC: C07K14/705
CPC classification number: A61K48/00 , A61K9/0019 , A61K38/00 , C07K14/705 , C07K2319/30 , C07K2319/32
Abstract: This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
Abstract translation: 本发明提供了治疗患有肿瘤的受试者的方法和用于抑制受试者血管生成的方法，所述方法包括向受试者施用有效量的包含Notch受体蛋白的细胞外结构域的物质组合物， 生命增加部分。 本发明还提供了包含Notch4受体蛋白的细胞外结构域的物质组合物，其可操作地附着于半衰期增加的部分。 本发明还提供了一种制造品。 最后，本发明提供了可复制载体，其编码包含可操作地附着于半衰期增加部分的Notch受体蛋白的细胞外结构域的多肽，包含该可复制载体的宿主载体系统和产生该多肽的方法。
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Patent Agency Ranking
公开(公告)号：US20170306006A1
公开(公告)日：2017-10-26
申请号：US15641712
申请日：2017-07-05
Applicant: Jan Kitajewski , Carrie Shawber , Thaned Kangsamaksin
Inventor： Jan Kitajewski , Carrie Shawber , Thaned Kangsamaksin
IPC: C07K16/18 , C07K14/705 , A61K38/17 , C07K19/00 , C07K14/71 , C07K14/715 , C07K16/28
CPC classification number: C07K16/18 , A61K38/177 , A61K38/1774 , A61K38/179 , A61K38/1793 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/283 , C07K19/00 , C07K2319/30 , C07K2319/32
Abstract: Provided herein are Notch1 fusion proteins. These fusion proteins comprise consecutive amino acids the sequence of which, commencing at the N-terminus of the fusion protein, is identical to the sequence of the amino acids in an extracellular domain of a human Notch1 receptor protein and an Fc portion of an antibody. The amino acid sequence of the extracellular domain (ECD) of the human Notch1 receptor protein commences with the amino acid present at the N-terminus of EGF-like repeat 10 and extends at least through the C-terminal amino acid of EGF-like repeat 23. The N-terminal portion of the ECD of the human Notch1 receptor protein may extend up to the C-terminal amino acid of EGF-like repeat 24 or may extend up to the C-terminal amino acid of EGF-like repeat 36. Compositions of these fusion proteins are also provided. Also provided are methods of treating age-related macular degeneration (AMD), diabetic retinopathy and cancer using the fusion proteins described herein.
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7.发明申请公开(公告)号：US20160115217A1
公开(公告)日：2016-04-28
申请号：US14844642
申请日：2015-09-03
Applicant: Jan Kitajewski , Carrie Shawber
Inventor： Jan Kitajewski , Carrie Shawber
IPC: C07K14/705
CPC classification number: C07K14/705 , A61K38/00 , C07K2319/02 , C07K2319/30
Abstract: This invention provides a fusion protein comprising a signal peptide, an extracellular domain of human Notch receptor protein and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject having a tumor, a method for inhibiting angiogenesis in a subject, a method for treating a subject having ovarian cancer, and a method for treating a subject having a metabolic disorder, comprising administering to the subject an amount of the above fusion protein effective to treat the subject. This invention further provides uses of the above fusion protein for the preparation of a pharmaceutical composition for the treatment of a subject having a tumor, for inhibiting angiogenesis in a subject, for treating a subject having ovarian cancer, and for treating a subject having a metabolic disorder.
Abstract translation: 本发明提供了包含信号肽，人Notch受体蛋白质的细胞外结构域和与其结合的抗体的Fc部分的融合蛋白质。 本发明还提供了治疗患有肿瘤的受试者的方法，用于抑制受试者血管发生的方法，用于治疗患有卵巢癌的受试者的方法，以及用于治疗具有代谢紊乱的受试者的方法，所述方法包括对所述受试者施用 上述融合蛋白有效治疗受试者的量。 本发明还提供了上述融合蛋白用于制备用于治疗患有肿瘤的受试者，用于抑制受试者的血管生成，用于治疗患有卵巢癌的受试者的药物组合物的用途，以及用于治疗具有代谢 紊乱。
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公开(公告)号：US09127085B2
公开(公告)日：2015-09-08
申请号：US12733329
申请日：2008-08-22
Applicant: Jan Kitajewski , Carrie Shawber
Inventor： Jan Kitajewski , Carrie Shawber
IPC: C07K14/705 , A61K38/00
CPC classification number: C07K14/705 , A61K38/00 , C07K2319/02 , C07K2319/30
Abstract: This invention provides a fusion protein comprising a single peptide, an extracellular domain of human Notch receptor protein and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject having a tumor, a method for inhibiting angiogenesis in a subject, a method for treating a subject having ovarian cancer, and a method for treating a subject having a metabolic disorder, comprising administering to the subject an amount of the above fusion protein effective to treat the subject. This invention further provides uses of the above fusion protein for the preparation of a pharmaceutical composition for the treatment of a subject having a tumor, for inhibiting angiogenesis in a subject, for treating a subject having ovarian cancer, and for treating a subject having a metabolic disorder.
Abstract translation: 本发明提供了包含单个肽，人类Notch受体蛋白质的细胞外结构域和与之结合的抗体的Fc部分的融合蛋白质。 本发明还提供了治疗患有肿瘤的受试者的方法，用于抑制受试者血管发生的方法，用于治疗患有卵巢癌的受试者的方法，以及用于治疗具有代谢紊乱的受试者的方法，所述方法包括对所述受试者施用 上述融合蛋白有效治疗受试者的量。 本发明还提供了上述融合蛋白用于制备用于治疗患有肿瘤的受试者，用于抑制受试者的血管生成，用于治疗患有卵巢癌的受试者的药物组合物的用途，以及用于治疗具有代谢 紊乱。
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公开(公告)号：US09738708B2
公开(公告)日：2017-08-22
申请号：US14349975
申请日：2012-10-04
Applicant: Jan Kitajewski , Carrie Shawber , Thaned Kangsamaksin
Inventor： Jan Kitajewski , Carrie Shawber , Thaned Kangsamaksin
IPC: C07K14/705 , C07K14/71 , C07K14/715 , C07K19/00 , A61K38/17 , C07K16/28 , C07K16/18
CPC classification number: C07K16/18 , A61K38/177 , A61K38/1774 , A61K38/179 , A61K38/1793 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/283 , C07K19/00 , C07K2319/30 , C07K2319/32
Abstract: Provided herein are Notch1 fusion proteins. These fusion proteins comprise consecutive amino acids the sequence of which, commencing at the N-terminus of the fusion protein, is identical to the sequence of the amino acids in an extracellular domain of a human Notch1 receptor protein and an Fc portion of an antibody. The amino acid sequence of the extracellular domain (ECD) of the human Notch1 receptor protein commences with the amino acid present at the N-terminus of BGF-like repeat 10 and extends at least through the C-terminal amino acid of EGF-like repeat 23. The N-terminal portion of the ECD of the human Notch1 receptor protein may extend up to the C-terminal amino acid of EGF-like repeat 24 or may extend up to the C-terminal amino acid of EGF-like repeat 36. Compositions of these fusion proteins are also provided. Also provided are methods of treating age-related macular degeneration (AND), diabetic retinopathy and cancer using the fusion proteins described herein.
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10.发明授权Human Notch3 based fusion proteins as decoy inhibitors of Notch3 signaling 有权人Notch3基融合蛋白作为Notch3信号传导的诱杀抑制剂公开(公告)号：US09475855B2
公开(公告)日：2016-10-25
申请号：US13060254
申请日：2009-08-21
Applicant: Jan Kitajewski , Carrie Shawber
Inventor： Jan Kitajewski , Carrie Shawber
IPC: C07K14/705 , C07K14/71 , C07K14/715 , C07K16/46 , C07K19/00 , C07K14/485 , A61K38/17 , A61K39/395 , A61K39/00
CPC classification number: C07K14/485 , A61K38/177 , A61K38/179 , A61K38/1793 , A61K39/395 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/46 , C07K2319/00 , C07K2319/02 , C07K2319/30
Abstract: This invention provides a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is any integer from 12 to 34, and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject having a tumor, a method for inhibiting angiogenesis in a subject, a method for treating a subject having ovarian cancer, and a method for treating a subject having a metabolic disorder, comprising administering to the subject an amount of the above fusion protein effective to treat the subject. This invention further provides uses of the above fusion protein for the preparation of a pharmaceutical composition for the treatment of a subject having a tumor, for inhibiting angiogenesis in a subject, for treating a subject having ovarian cancer, and for treating a subject having a metabolic disorder.
Abstract translation: 本发明提供了融合蛋白，其包含信号肽EGF重复人Notch3受体蛋白的细胞外结构域的1-X，其中X为12至34的任何整数，以及与其结合的抗体的Fc部分。 本发明还提供了治疗患有肿瘤的受试者的方法，用于抑制受试者血管发生的方法，用于治疗患有卵巢癌的受试者的方法，以及用于治疗具有代谢紊乱的受试者的方法，所述方法包括对所述受试者施用 上述融合蛋白有效治疗受试者的量。 本发明还提供了上述融合蛋白用于制备用于治疗患有肿瘤的受试者，用于抑制受试者的血管生成，用于治疗患有卵巢癌的受试者的药物组合物的用途，以及用于治疗具有代谢 紊乱。
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