Abstract:
A therapeutic agent for tumor for combined use of a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and a compound represented by Formula (II): wherein R1 is C1-6 alkyl or C3-8 cycloalkyl, R2 is a hydrogen atom or C1-6 alkoxy, and R3 is a hydrogen atom or a halogen atom, exhibits an excellent antitumor effect compared to cases where these are individually used.
Abstract:
Compounds represented by the following general formula: wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—), Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.), salts thereof or hydrates of the foregoing.
Abstract:
This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
Abstract:
A video reproducing apparatus includes a video data memory for storing video data and a video data table for storing information about whether or not given items of the video data in the video data memory have been reproduced. A backup power supply unit backs up the information in the video data table when power is removed. A song category designation input unit is provided for inputting the song category designated, a video reproducing unit is provided for reproducing video data, and a background video control unit is provided for controlling the component units configured. On the basis of the information held in the video data table, the background video control unit determines whether or not any unreproduced video data remains in the video data belonging to the song category designated by the song category designation input unit. If unreproduced video data is found to exist, the control unit instructs the video reproducing unit to reproduce that unreproduced video data.
Abstract:
Disclosed is an improved fire alarm system for an information providing system having a plurality of terminal devices for providing information to a plurality of operators, respectively. The fire alarm system is provided with a fire detecting sensors. If a fire is detected, a predetermined signal is transmitted to a controller. The controller controls each of the plurality of terminal devices to indicate an alarm information to the operator when the predetermined signal is received.
Abstract:
The music number is input through the panel switch arranged in the music accompanying apparatus. The modulated music number signal by the modulation-demodulation device is transmitted to the control apparatus through the coaxial cable. In the control apparatus, the music number data signal is received through the coaxial cable, and further demodulated into the music number data by the modulation-demodulation device. The controller reads out the various music data. At the same time, the controller controls the four video disc devices so that the four video picture data each of which is corresponded to the different music genre, are reproduced by the video disc devices. Thereafter, both the various music data and the four video picture data are mutually superimposed through the head amplifier after modulated by each of the modulators and transmitted to each of the music accompanying apparatuses through the coaxial cable. In the music accompanying apparatus, one of the four video picture data is selected by the video tuner based on the song tone data and both the video picture and the song text are displayed on the video monitor at the same time through picture synthesizing circuit.
Abstract:
An entertainment apparatus includes a loudspeaker for producing an orchestral background for singer's accompaniment and a TV monitor for displaying a background video relevant to a song sang by the singer. In a compact disk, accompaniment data and corresponding song text data are recorded with respect to each of a plurality of songs, and in a video disk, stored are a plurality of background video data each being used in conjunction with a song selected. When a desired song is selected, its accompaniment data and the corresponding song text data are read from the compact disk and one of the plurality of background video data is read from the video disk. The song text data is superimposed on the background video data so that the song text and the background video are superimposedly displayed on the TV monitor. In synchronous with the display on the TV monitor, the accompaniment data is reproduced from the loudspeaker to give an orchestral background for singers.
Abstract:
Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having cancer (e.g., thyroid cancer, kidney cancer), suspected of having cancer, or at risk of developing cancer.
Abstract:
This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
Abstract:
A therapeutic agent for tumor for combined use of a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and a compound represented by Formula (II): wherein R1 is C1-6 alkyl or C3-8 cycloalkyl, R2 is a hydrogen atom or C1-6 alkoxy, and R3 is a hydrogen atom or a halogen atom, exhibits an excellent antitumor effect compared to cases where these are individually used.