发明申请
US20150335726A1 Filovirus Consensus Antigens, Nucleic Acid Constructs And Vaccines Made Therefrom, And Methods Of Using Same
有权
纤维病毒共识抗原，核酸构建体和疫苗，以及使用相同的方法
- 专利标题： Filovirus Consensus Antigens, Nucleic Acid Constructs And Vaccines Made Therefrom, And Methods Of Using Same
- 专利标题（中）： 纤维病毒共识抗原，核酸构建体和疫苗，以及使用相同的方法
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申请号： US14391952申请日： 2013-04-12
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公开(公告)号： US20150335726A1公开(公告)日： 2015-11-26
- 发明人: David B. Weiner , Devon Shedlock
- 申请人： David B. Weiner , Devon Shedlock
- 国际申请： PCT/US13/36413 WO 20130412
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C12N7/00
摘要：
Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.
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