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    Filovirus Consensus Antigens, Nucleic Acid Constructs And Vaccines Made Therefrom, And Methods Of Using Same
    1.
    发明申请
    Filovirus Consensus Antigens, Nucleic Acid Constructs And Vaccines Made Therefrom, And Methods Of Using Same 有权
    纤维病毒共识抗原，核酸构建体和疫苗，以及使用相同的方法

    公开(公告)号：US20150335726A1

    公开(公告)日：2015-11-26

    申请号：US14391952

    申请日：2013-04-12

    申请人： David B. Weiner ,  Devon Shedlock

    发明人： David B. Weiner ,  Devon Shedlock

    IPC分类号： A61K39/12 ,  C12N7/00

    CPC分类号： A61K39/12 ,  A61K38/20 ,  A61K38/208 ,  A61K38/2086 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/70 ,  A61N1/327 ,  C07K14/005 ,  C07K2319/02 ,  C12N7/00 ,  C12N2760/14122 ,  C12N2760/14134 ,  C12N2760/14171 ,  C12N2760/14222 ,  C12N2760/14234 ,  C12N2760/14271

    摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.

    摘要翻译： 公开了包含一个或多个核酸序列的核酸分子和组合物，所述核酸序列编码包括共有的马尔堡病毒filov病毒糖蛋白MARV GP免疫原，共有的埃博病毒苏丹filovirus糖蛋白SEBOV GP免疫原和共有的埃博病毒扎伊尔糖蛋白ZEBOV GP免疫原的共有的病毒免疫原。 编码序列任选地包括编码信号肽的可操作的连锁编码序列。 公开了免疫调节方法和诱导针对病毒，尤其是马尔堡病毒，埃及病毒苏丹和埃博拉病毒扎伊尔的免疫应答的方法。 公开了防止病毒感染的方法，特别是马尔堡病毒，埃及病毒苏丹和埃博拉病毒扎伊尔的感染，以及治疗感染了病毒感染的个体，特别是马尔堡病毒，埃博病毒苏丹和埃博拉病毒扎伊尔感染的方法。 公知共识的病毒蛋白。