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    Filovirus Consensus Antigens, Nucleic Acid Constructs And Vaccines Made Therefrom, And Methods Of Using Same
    1.
    发明申请
    Filovirus Consensus Antigens, Nucleic Acid Constructs And Vaccines Made Therefrom, And Methods Of Using Same 有权
    纤维病毒共识抗原，核酸构建体和疫苗，以及使用相同的方法

    公开(公告)号：US20150335726A1

    公开(公告)日：2015-11-26

    申请号：US14391952

    申请日：2013-04-12

    申请人： David B. Weiner ,  Devon Shedlock

    发明人： David B. Weiner ,  Devon Shedlock

    IPC分类号： A61K39/12 ,  C12N7/00

    CPC分类号： A61K39/12 ,  A61K38/20 ,  A61K38/208 ,  A61K38/2086 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/70 ,  A61N1/327 ,  C07K14/005 ,  C07K2319/02 ,  C12N7/00 ,  C12N2760/14122 ,  C12N2760/14134 ,  C12N2760/14171 ,  C12N2760/14222 ,  C12N2760/14234 ,  C12N2760/14271

    摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.

    摘要翻译： 公开了包含一个或多个核酸序列的核酸分子和组合物，所述核酸序列编码包括共有的马尔堡病毒filov病毒糖蛋白MARV GP免疫原，共有的埃博病毒苏丹filovirus糖蛋白SEBOV GP免疫原和共有的埃博病毒扎伊尔糖蛋白ZEBOV GP免疫原的共有的病毒免疫原。 编码序列任选地包括编码信号肽的可操作的连锁编码序列。 公开了免疫调节方法和诱导针对病毒，尤其是马尔堡病毒，埃及病毒苏丹和埃博拉病毒扎伊尔的免疫应答的方法。 公开了防止病毒感染的方法，特别是马尔堡病毒，埃及病毒苏丹和埃博拉病毒扎伊尔的感染，以及治疗感染了病毒感染的个体，特别是马尔堡病毒，埃博病毒苏丹和埃博拉病毒扎伊尔感染的方法。 公知共识的病毒蛋白。

    Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same
    10.
    发明授权
    Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same 有权
    使用密码子优化的IL-15的疫苗和免疫治疗剂及其使用方法

    公开(公告)号：US08178660B2

    公开(公告)日：2012-05-15

    申请号：US12160766

    申请日：2007-01-12

    申请人： David B. Weiner ,  Michele Kutzler

    发明人： David B. Weiner ,  Michele Kutzler

    IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K48/00

    CPC分类号： C07K14/5443 ,  A61K2039/55522 ,  Y02A50/394

    摘要： Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid molecules with additional modifications such as the absence of coding sequences for IL-15 signal sequences and/or the absence of IL-15 untranslated sequences and/or inclusion of non-IL-15 signal sequences are also disclosed. Vectors, including plasmids and viral vectors, comprising such nucleic acid molecules; and to host cells comprising such nucleic acid molecules are disclosed as well as methods of using such nucleic acid molecules alone or in combination with nucleic acid sequences encoding immunogens which are part of the nucleic acid molecules and/or part of a different nucleic acid molecule. Recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed.

    摘要翻译： 公开了编码IL-15或其片段的核酸分子，其以比具有IL-15的天然编码序列的核酸分子更高的水平表达蛋白质。 还公开了具有附加修饰的核酸分子，例如不存在IL-15信号序列的编码序列和/或不存在IL-15非翻译序列和/或包含非IL-15信号序列。 包括这种核酸分子的载体，包括质粒和病毒载体; 以及包含这种核酸分子的宿主细胞以及使用这些核酸分子单独或与编码作为核酸分子和/或不同核酸分子的一部分的免疫原的核酸序列组合的方法。 公开了重组疫苗和编码融合蛋白的活减毒病原体及其使用方法。