发明申请
US20150344926A1 Enzyme Hyaluronan-Lyase, Method of Production Thereof, Use Thereof and Method of Preparation of Low-Molecular Hyaluronan
审中-公开
酵素透明质酸裂解酶，其生产方法及其用途及低分子透明质酸的制备方法
- 专利标题： Enzyme Hyaluronan-Lyase, Method of Production Thereof, Use Thereof and Method of Preparation of Low-Molecular Hyaluronan
- 专利标题（中）： 酵素透明质酸裂解酶，其生产方法及其用途及低分子透明质酸的制备方法
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申请号： US14430731申请日： 2013-09-26
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公开(公告)号： US20150344926A1公开(公告)日： 2015-12-03
- 发明人: Lenka Knorova , Dzianis Smirnou , Veronika Leierova , Martin Krcmar , Lukas Franke , Vladimir Velebny
- 申请人： CONTIPRO BIOTECH S.R.O.
- 申请人地址： CZ Dolní Dobrouc
- 专利权人： Contipro Biotech s.r.o.,
- 当前专利权人： Contipro Biotech s.r.o.,
- 当前专利权人地址： CZ Dolní Dobrouc
- 优先权： CZPV2012-664 20120927
- 国际申请： PCT/CZ2013/000116 WO 20130926
- 主分类号： C12P19/26
- IPC分类号： C12P19/26 ; C12N9/88
摘要：
The invention relates to an enzyme which is able to degrade hyaluronic acid and which is produced by fungi of the genus Fistulina (especially Fistulina hepatica). The degradation proceeds by lyase mechanism in which double bonds between C4 and C5 of glucuronic acid are formed. The invention also includes the process of preparation and purification of the enzyme and a possible practical use thereof for the preparation of low-molecular hyaluronan or of cosmetic or pharmaceutical devices. Further, the invention relates to the method of preparation of low-molecular hyaluronan.
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