发明申请
- 专利标题： EFFECTOR T CELL RSISTANCE
- 专利标题（中）： 效应T细胞密度
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申请号： US14764899申请日： 2014-01-30
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公开(公告)号： US20150362508A1公开(公告)日： 2015-12-17
- 发明人: Jane Hoyt Buckner
- 申请人： BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
- 申请人地址： US WA Seattle
- 专利权人： Benaroya Research Institute at Virginia Mason
- 当前专利权人： Benaroya Research Institute at Virginia Mason
- 当前专利权人地址： US WA Seattle
- 国际申请： PCT/US2014/013838 WO 20140130
- 主分类号： G01N33/68
- IPC分类号： G01N33/68
摘要：
A method for identifying an autoimmune or demyelinating disease in a subject is described. The method includes (a) FIRST COHORT obtaining a sample comprising CD4′ T cells from a subject; (b) determining a level of IL-6 responsiveness of CD4+ T cells from the sample; (c) comparing the level of IL-6 responsiveness determined in step (b) with a level of IL-6 responsiveness of CD4+ T cells in a sample from a healthy subject; and (d) identifying the subject as having an autoimmune or demyelinating disease based upon an elevated level of IL-6 responsiveness in the subject. Biomarkers include, for example, IL-6Rα and/or pSTAT3. Methods for identifying and characterizing multiple sclerosis and relapsing-remitting multiple sclerosis are also described.
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