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    Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression
    1.
    发明授权
    Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression 有权
    通过增加托普拉斯汀的表达来促进弹性变形和弹性蛋白纤维形成的方法

    公开(公告)号：US08367619B2

    公开(公告)日：2013-02-05

    申请号：US12526625

    申请日：2008-02-07

    申请人： Thomas N. Wight ,  Mervyn Merrilees

    发明人： Thomas N. Wight ,  Mervyn Merrilees

    IPC分类号： A61K38/16 ,  A61K38/00 ,  C12N5/00 ,  C12N5/02 ,  A61P43/00 ,  A61P19/00 ,  A61P17/00

    CPC分类号： C07K14/4725

    摘要： Compositions and methods are provided for promoting elastin fiber formation (elastogenesis) in a cell, including methods that comprise contacting a cell that is capable of elastogenesis with (i) a mutated biglycan polypeptide that lacks chondroitin sulphate proteoglycan chains, (ii) a versican V3 isoform polypeptide that lacks most or all of the polypeptide regions encoded by one or more of exons 4, 5 or 6 or by exons 9-10 or 11-13, and/or with (iii) metastatin.

    摘要翻译： 提供了用于促进细胞中弹性蛋白纤维形成（弹性生成）的组合物和方法，包括使能够弹性发生的细胞与（i）缺乏硫酸软骨素蛋白聚糖链的突变的大豆聚糖多肽接触的方法，（ii）多核苷酸V3 缺少由一个或多个外显子4,5或6或外显子9-10或11-13编码的大部分或全部多肽区域和/或与（iii）转移物组成的异构体多肽。

    COMPOSITIONS AND METHODS FOR DETECTING ALLERGEN REACTIVE TH2 CELLS
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR DETECTING ALLERGEN REACTIVE TH2 CELLS 有权

    公开(公告)号：US20220326217A1

    公开(公告)日：2022-10-13

    申请号：US17640548

    申请日：2020-09-04

    申请人： Benaroya Research Institute at Virginia Mason

    发明人： Eric E. Wambre ,  Justine J. Calise

    IPC分类号： G01N33/50 ,  G01N33/68 ,  A61P37/08

    摘要： Provided are methods and compositions for labeling an allergen-specific pathogenic CD4+ T-cell. The method can comprise contacting a cell population comprising CD4+ T cells with a suspected allergen to provide a challenged cell population, contacting the challenged cell population, or a subpopulation thereof, with a first molecule that specifically binds to a biomarker for an allergen-specific pathogenic T cell, wherein binding of the first molecule to the biomarker on a CD4+ cell indicates the cell is an allergen-specific pathogenic CD4+ T cell, and detecting binding of the first molecule to a CD4+ cell, wherein binding to the cell indicates the cell is an allergen-specific pathogenic CD4+ T cell. The method is applicable to monitoring the presence of allergen-specific pathogenic CD4+ T cells and/or efficacy of immunotherapy for allergies in a subject.

    COMPOSITIONS AND METHODS FOR TREATING AIRWAY INFLAMMATORY DISEASES
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING AIRWAY INFLAMMATORY DISEASES 审中-公开
    用于治疗气道炎症疾病的组合物和方法

    公开(公告)号：US20120321665A1

    公开(公告)日：2012-12-20

    申请号：US13523736

    申请日：2012-06-14

    申请人： Paul Bollyky ,  Gerald T. Nepom ,  Michael G. Kinsella

    发明人： Paul Bollyky ,  Gerald T. Nepom ,  Michael G. Kinsella

    IPC分类号： A61K39/35 ,  A61P11/06 ,  A61K39/36 ,  A61P11/08 ,  A61P11/04 ,  A61P11/00 ,  A61P37/08

    CPC分类号： A61K39/35 ,  A61K2039/577 ,  A61K2039/6087

    摘要： A composition for treating an airway inflammatory disease having high molecular weight, crosslinked hyaluronan and at least one aeroallergen is provided. A method of inducing immune tolerance to one or more aeroallergens in a mammalian subject suffering from or at risk of developing an airway inflammatory disease, and a method of treating a human subject suffering from or at risk of developing an airway inflammatory disease or condition of the lungs are also provided.

    摘要翻译： 提供了一种用于治疗具有高分子量的气道炎性疾病，交联透明质酸和至少一种空气过敏原的组合物。 在患有或有风险发生气道炎症性疾病的哺乳动物受试者中诱导对一种或多种空气过敏原的免疫耐受的方法，以及治疗患有或有发生气道炎性疾病或风险的人类受试者的方法 还提供肺。

    4-METHYLUMBELLIFERONE TREATMENT FOR IMMUNE MODULATION
    6.
    发明申请
    4-METHYLUMBELLIFERONE TREATMENT FOR IMMUNE MODULATION 审中-公开
    用于免疫调节的4-甲基咪唑烷酮治疗

    公开(公告)号：US20160184262A1

    公开(公告)日：2016-06-30

    申请号：US14911533

    申请日：2014-08-12

    申请人： BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

    发明人： Paul L. Bollyky ,  Nadine Nagy ,  Thomas Wight ,  Hedwich F. Kuipers

    IPC分类号： A61K31/37 ,  A61K31/7048

    CPC分类号： A61K31/37 ,  A61K31/7048

    摘要： Compositions for treating autoimmune, allergic, or atopic disease comprising a compound that inhibits hyaluronan synthesis and a pharmaceutically acceptable carrier are described. In some embodiments, the compound that inhibits hyaluronan synthesis is 4-methylumbelliferone or a metabolite of 4-methylumbelliferone. Methods for treating autoimmune diabetes, multiple sclerosis and/or autoimmune demyelination, including administering to the subject a composition having a compound in an amount effective to inhibit hyaluronan synthesis in a mammalian subject, are also described.

    摘要翻译： 描述了用于治疗自身免疫性，过敏性或特应性疾病的组合物，其包含抑制透明质酸合成的化合物和药学上可接受的载体。 在一些实施方案中，抑制透明质酸合成的化合物是4-甲基伞形酮或4-甲基伞形酮的代谢物。 还描述了治疗自身免疫性糖尿病，多发性硬化和/或自身免疫性脱髓鞘的方法，包括向受试者施用具有有效抑制哺乳动物受试者中透明质酸合成的量的化合物的组合物。

    EFFECTOR T CELL RSISTANCE
    7.
    发明申请
    EFFECTOR T CELL RSISTANCE 审中-公开
    效应T细胞密度

    公开(公告)号：US20150362508A1

    公开(公告)日：2015-12-17

    申请号：US14764899

    申请日：2014-01-30

    申请人： BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON

    发明人： Jane Hoyt Buckner

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6869 ,  G01N33/564 ,  G01N2333/47 ,  G01N2333/5412 ,  G01N2333/7155 ,  G01N2800/24 ,  G01N2800/285 ,  G01N2800/52

    摘要： A method for identifying an autoimmune or demyelinating disease in a subject is described. The method includes (a) FIRST COHORT obtaining a sample comprising CD4′ T cells from a subject; (b) determining a level of IL-6 responsiveness of CD4+ T cells from the sample; (c) comparing the level of IL-6 responsiveness determined in step (b) with a level of IL-6 responsiveness of CD4+ T cells in a sample from a healthy subject; and (d) identifying the subject as having an autoimmune or demyelinating disease based upon an elevated level of IL-6 responsiveness in the subject. Biomarkers include, for example, IL-6Rα and/or pSTAT3. Methods for identifying and characterizing multiple sclerosis and relapsing-remitting multiple sclerosis are also described.

    摘要翻译： 描述了用于鉴定个体中自身免疫或脱髓鞘疾病的方法。 该方法包括：（a）首先获得包含受试者的CD4 + T细胞的样品; （b）测定样品中CD4 + T细胞的IL-6应答水平; （c）比较步骤（b）中确定的IL-6应答水平与来自健康受试者的样品中CD4 + T细胞的IL-6应答水平; 和（d）基于受试者的IL-6反应性水平升高，将受试者鉴定为具有自身免疫性或脱髓鞘性疾病。 生物标志物包括例如IL-6Rα和/或pSTAT3。 还描述了用于鉴定和表征多发性硬化和复发性多发性硬化症的方法。

    Methods of generating antigen-specific CD4+CD25+regulatory T cells, compositions and methods of use
    8.
    发明授权
    Methods of generating antigen-specific CD4+CD25+regulatory T cells, compositions and methods of use 有权
    产生抗原特异性CD4 + CD25 +调节性T细胞的方法，组合物和使用方法

    公开(公告)号：US08053235B2

    公开(公告)日：2011-11-08

    申请号：US11261429

    申请日：2005-10-28

    申请人： Jane H. Buckner ,  Mindi R. Walker

    发明人： Jane H. Buckner ,  Mindi R. Walker

    IPC分类号： A01N1/02 ,  C12N5/071

    CPC分类号： C12N5/0636 ,  A61K39/0008 ,  A61K39/001 ,  A61K2035/122 ,  A61K2039/5158 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2502/11

    摘要： The present invention provides methods for generating mammalian T cell populations comprising antigen-specific CD4+CD25+ regulatory T cells from freshly isolated CD4+CD25− T cells. The method comprises selecting CD4+CD25− T cells from a sample obtained from a mammalian subject; determining the MHC Class II type of the subject; inducing the generation of antigen-specific regulatory T cells by contacting the isolated CD4+CD25− T cells in a culture vessel with an induction agent for a time period sufficient to generate antigen-specific CD4+CD25+ regulatory T cells; and selecting the CD4+CD25+ antigen-specific regulatory T cells by sorting the cells in the induction culture with a selection agent comprising at least one artificial multimeric MHC Class II/peptide complex that corresponds to the MHC Class II type of the subject.

    摘要翻译： 本发明提供了用于从新分离的CD4 + CD25-T细胞产生包含抗原特异性CD4 + CD25 +调节性T细胞的哺乳动物T细胞群的方法。 该方法包括从哺乳动物受试者获得的样品中选择CD4 + CD25-T细胞; 确定受试者的MHC II类型; 通过使培养容器中的分离的CD4 + CD25-T细胞与诱导剂接触足以产生抗原特异性CD4 + CD25 +调节性T细胞的时间段来诱导产生抗原特异性调节性T细胞; 以及通过用包含至少一种对应于受试者的MHC II类类型的人造多聚体MHC II类/肽复合物的选择剂分选诱导培养物中的细胞来选择CD4 + CD25 +抗原特异性调节性T细胞。

    TUMOR ASSOCIATED ANTIGENS AND METHODS OF USING THE SAME
    9.
    发明申请
    TUMOR ASSOCIATED ANTIGENS AND METHODS OF USING THE SAME 审中-公开
    肿瘤相关抗原及其使用方法

    公开(公告)号：US20080032316A1

    公开(公告)日：2008-02-07

    申请号：US11697639

    申请日：2007-04-06

    申请人： Brad Nelson ,  Bradley Stone

    发明人： Brad Nelson ,  Bradley Stone

    IPC分类号： G01N33/574

    CPC分类号： G01N33/574 ,  G01N33/564 ,  G01N33/6854

    摘要： The present invention provides methods and compositions for the diagnosis of hyperproliferative disease and autoimmune disease. Tumor associated antigens, nucleic acids encoding them and antibodies to the tumor associated antigens are provided for the diagnosis of hyperproliferative disease, such as, for example, ovarian cancer, breast cancer, lung cancer, colorectal cancer, and other epithelial cancers, and for the diagnosis of autoimmune disease.

    摘要翻译： 本发明提供了用于诊断过度增殖性疾病和自身免疫疾病的方法和组合物。 肿瘤相关抗原，编码它们的核酸和与肿瘤相关抗原的抗体被提供用于诊断过度增殖性疾病，例如卵巢癌，乳腺癌，肺癌，结肠直肠癌和其它上皮癌，并且对于 诊断自身免疫性疾病。