公开(公告)号：US20150362508A1

公开(公告)日：2015-12-17

申请号：US14764899

申请日：2014-01-30

申请人： BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON

发明人： Jane Hoyt Buckner

IPC分类号： G01N33/68

CPC分类号： G01N33/6869 ,  G01N33/564 ,  G01N2333/47 ,  G01N2333/5412 ,  G01N2333/7155 ,  G01N2800/24 ,  G01N2800/285 ,  G01N2800/52

摘要： A method for identifying an autoimmune or demyelinating disease in a subject is described. The method includes (a) FIRST COHORT obtaining a sample comprising CD4′ T cells from a subject; (b) determining a level of IL-6 responsiveness of CD4+ T cells from the sample; (c) comparing the level of IL-6 responsiveness determined in step (b) with a level of IL-6 responsiveness of CD4+ T cells in a sample from a healthy subject; and (d) identifying the subject as having an autoimmune or demyelinating disease based upon an elevated level of IL-6 responsiveness in the subject. Biomarkers include, for example, IL-6Rα and/or pSTAT3. Methods for identifying and characterizing multiple sclerosis and relapsing-remitting multiple sclerosis are also described.

摘要翻译： 描述了用于鉴定个体中自身免疫或脱髓鞘疾病的方法。 该方法包括：（a）首先获得包含受试者的CD4 + T细胞的样品; （b）测定样品中CD4 + T细胞的IL-6应答水平; （c）比较步骤（b）中确定的IL-6应答水平与来自健康受试者的样品中CD4 + T细胞的IL-6应答水平; 和（d）基于受试者的IL-6反应性水平升高，将受试者鉴定为具有自身免疫性或脱髓鞘性疾病。 生物标志物包括例如IL-6Rα和/或pSTAT3。 还描述了用于鉴定和表征多发性硬化和复发性多发性硬化症的方法。