Quantum processor based techniques minimize an objective function for example by operating the quantum processor as a sample generator providing low-energy samples from a probability distribution with high probability. The probability distribution is shaped to assign relative probabilities to samples based on their corresponding objective function values until the samples converge on a minimum for the objective function. Problems having a number of variables and/or a connectivity between variables that does not match that of the quantum processor may be solved. Interaction with the quantum processor may be via a digital computer. The digital computer stores a hierarchical stack of software modules to facilitate interacting with the quantum processor via various levels of programming environment, from a machine language level up to an end-use applications level.