发明申请
US20160046570A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES
审中-公开
N-羟基甲酰胺和N-羟基-N-亚磺酰胺衍生物
- 专利标题： N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES
- 专利标题（中）： N-羟基甲酰胺和N-羟基-N-亚磺酰胺衍生物
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申请号： US14927658申请日： 2015-10-30
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公开(公告)号： US20160046570A1公开(公告)日： 2016-02-18
- 发明人: John P. Toscano , Art Sutton , Vincent Jacob Kalish , Frederick Arthur Brookfield , Stephen Martin Courtney , Lisa Marie Frost
- 申请人： The Johns Hopkins University , Cardioxyl Pharmaceuticals, Inc.
- 主分类号： C07C311/48
- IPC分类号： C07C311/48 ; C07D295/195 ; C07D309/12 ; C07D211/46 ; C07D317/30 ; C07D241/04 ; C07D401/04 ; C07D413/04 ; C07D211/58 ; C07D207/06 ; C07D211/62 ; C07D213/59 ; C07D233/38 ; C07D241/08 ; C07D209/48 ; C07D207/16 ; C07D333/34 ; C07D307/82 ; C07D213/71 ; C07C317/32 ; C07C311/51
摘要：
The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.