发明申请
US20160052991A1 MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM
审中-公开
突变型G蛋白偶联受体及其选择方法
- 专利标题： MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM
- 专利标题（中）： 突变型G蛋白偶联受体及其选择方法
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申请号： US14836820申请日： 2015-08-26
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公开(公告)号： US20160052991A1公开(公告)日： 2016-02-25
- 发明人: Richard Henderson , Christopher Gordon Tate , Francesca Magnani , Maria Josefa Serrano-Vega , Yoko Shibata , Antony Johannes Warne , Malcolm Peter Weir
- 申请人： Richard Henderson , Christopher Gordon Tate , Francesca Magnani , Maria Josefa Serrano-Vega , Yoko Shibata , Antony Johannes Warne , Malcolm Peter Weir
- 申请人地址： GB Hertfordshire
- 专利权人： Heptares Therapeutics Limited
- 当前专利权人： Heptares Therapeutics Limited
- 当前专利权人地址： GB Hertfordshire
- 优先权： GB0705450.5 20070322; GB0724052.6 20071208
- 主分类号： C07K14/72
- IPC分类号： C07K14/72
摘要：
The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.
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