发明申请
US20160068542A1 Enhanced Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells
审中-公开
大豆黄素类似物对人间充质干细胞的增强的成骨活性
- 专利标题： Enhanced Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells
- 专利标题（中）： 大豆黄素类似物对人间充质干细胞的增强的成骨活性
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申请号： US14781494申请日： 2014-04-04
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公开(公告)号： US20160068542A1公开(公告)日： 2016-03-10
- 发明人: Zhenzhen SHI , Amy STRONG , Stephen BOUE , Matthew BUROW , Bruce BUNNELL , Quan JIANG , Shilong ZHENG , Guangdi WANG
- 申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
- 国际申请： PCT/US2014/032908 WO 20140404
- 主分类号： C07D493/04
- IPC分类号： C07D493/04 ; A61K35/28 ; C07D311/04 ; A61K31/352
摘要：
Disclosed are daidzein analogs having the formula (I). Also disclosed are compositions, include a disclosed daidzein analogs, methods of preventing or treating bone disease or bone injury and/or stimulating bone growth, in a subject that include administering to the subject an effective amount of disclosed daidzein analog. Disclosed are isolated mesenchymal stem cell that has been altered by treatment a disclosed daidzein analog, daidzein, glycinol, glyceollin I, or glyceollin II, to increase the osteogenic potential of the mesenchymal stem cells.
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