Robotic pick-and-place automation is used to transfer oral solid pharmaceuticals from moveable trays or canisters. A variety of sensors are used in order to automatically verify that the oral solid pharmaceuticals have been properly placed in the desired oral solid pharmaceutical package locations precisely according to the patient prescription data. A pharmacist places oral solid pharmaceutical products within dispensing trays or canisters which are used to present the oral solid pharmaceutical products for picking and placing via the robotic pick-and-place machinery. Once the canister or tray is located adjacent the pick-and-place device, a further sensor or imaging unit associated with the pick-and-place device verifies that the oral solid pharmaceutical product presented by the tray or canister matches the size and shape and/or color of an expected oral solid pharmaceutical product that is to be placed within the packaging material in accordance with patient prescription data that is stored by a computer associated with the system. Additional sensors automatically verify that each individual oral solid pharmaceutical specified by a patient prescription have been deposited into each specified package location strictly in accordance with the patient prescription data.