The invention provides a non-invasive device (100) for skin rejuvenation using a treatment pressure below ambient pressure, and provides a method and a computer program product. The non-invasive device comprises a suction chamber (110) having a skin contact surface (115) comprising an opening (120) for exposing the skin tissue (200) to the suction chamber for applying a suction force to an outer surface (210) of the skin tissue. The opening in the suction chamber is less than 10 square millimeters. The suction chamber is dimensioned so as to allow it to be manually applied to the outer surface of the skin tissue. The non-invasive device further comprises a controller (140) for controlling a level of treatment pressure (Pt) inside the suction chamber (110) and for controlling an application time interval (Δt) of the treatment pressure for damaging an interface (225) between an epidermis layer (220) and a dermis layer (230) of the skin tissue.