Invention Application
US20160137989A1 METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION
审中-公开
通过HISTONE LYSE METHYLATION抑制基因转录的方法
- Patent Title: METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION
- Patent Title (中): 通过HISTONE LYSE METHYLATION抑制基因转录的方法
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Application No.: US15003174Application Date: 2016-01-21
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Publication No.: US20160137989A1Publication Date: 2016-05-19
- Inventor: Ming-ming Zhou , Shiraz Mujtaba
- Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Applicant Address: US NY New York
- Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US NY New York
- Main IPC: C12N9/10
- IPC: C12N9/10
Abstract:
The present invention relates to methods of suppressing the transcriptional expression of one or more genes by methylating the chromatin histone proteins of the one or more genes. Specifically, a viral SET domain histone lysine methyltransferase (vSET or vSET-like protein) methylates lysine 27 of a gene's histone protein 3 (H3-K27) thereby suppressing the transcription of the gene.
Public/Granted literature
- US10280408B2 Method of suppressing gene transcription through histone lysine methylation Public/Granted day:2019-05-07
Information query
