发明申请
US20160158377A1 BCL-XL Inhibitory Compounds and Antibody Drug Conjugates Including the Same
审中-公开
BCL-XL抑制剂及其抗体药物结合物
- 专利标题： BCL-XL Inhibitory Compounds and Antibody Drug Conjugates Including the Same
- 专利标题（中）： BCL-XL抑制剂及其抗体药物结合物
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申请号： US14963510申请日： 2015-12-09
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公开(公告)号： US20160158377A1公开(公告)日： 2016-06-09
- 发明人: Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
- 申请人： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; C07K16/18 ; C07D513/04 ; C07D417/14 ; C07D487/04
摘要：
Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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