发明申请
US20160222422A1 Xiamenmycin biosynthesis gene cluster, application and bacterial strain
审中-公开
厦门霉素生物合成基因簇,应用和细菌株
- 专利标题: Xiamenmycin biosynthesis gene cluster, application and bacterial strain
- 专利标题(中): 厦门霉素生物合成基因簇,应用和细菌株
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申请号: US14902342申请日: 2014-04-21
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公开(公告)号: US20160222422A1公开(公告)日: 2016-08-04
- 发明人: Jun Xu , Yong Yang , Ling FU , Minjuan Xu , Zhongyuan You
- 申请人: SHANGHAI JIAO TONG UNIVERSITY
- 优先权: CN201310273055.5 20130701
- 国际申请: PCT/CN2014/075784 WO 20140421
- 主分类号: C12P17/06
- IPC分类号: C12P17/06 ; C12N15/52
摘要:
The present invention involves the application of a gene cluster, and bacterial strains that used in the biosynthesis of Xiamenmycin. The nucleotide sequence of the gene cluster is showed as SEQ ID NO.1, with the whole length of 5189 base pairs. The present invention involves Streptomyces xiamenensis CGMCC No. 5670 and its mutant strain, and the method that how the mentioned bacterial strain produces Xiamenmycin. The present invention provides the strain sources by using Streptomyces xiamenensis, its mutant strains or genetically engineered microbial strains carring the above-mentioned Xiamenmycin biosynthesis gene cluster for cultivation and produce benzopyran compound Xiamenmycin through biosynthesis. The mutant strains can be used in industrial production.
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